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. 2007 Apr 12;446(7137):765-70.
doi: 10.1038/nature05760.

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis

Gaorav P Gupta  1 , Don X Nguyen, Anne C Chiang, Paula D Bos, Juliet Y Kim, Cristina Nadal, Roger R Gomis, Katia Manova-Todorova, Joan Massagué
Affiliations

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis

Gaorav P Gupta et al. Nature. .

Abstract

Metastasis entails numerous biological functions that collectively enable cancerous cells from a primary site to disseminate and overtake distant organs. Using genetic and pharmacological approaches, we show that the epidermal growth factor receptor ligand epiregulin, the cyclooxygenase COX2, and the matrix metalloproteinases 1 and 2, when expressed in human breast cancer cells, collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis. These findings reveal how aggressive primary tumorigenic functions can be mechanistically coupled to greater lung metastatic potential, and how such biological activities may be therapeutically targeted with specific drug combinations.

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Comment in

  • Cancer: division of labour.
    Christofori G. Christofori G. Nature. 2007 Apr 12;446(7137):735-6. doi: 10.1038/446735a. Nature. 2007. PMID: 17429382 No abstract available.

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