Tumour microenvironment: laminin 332 in squamous-cell carcinoma
- PMID: 17457303
- DOI: 10.1038/nrc2089
Tumour microenvironment: laminin 332 in squamous-cell carcinoma
Abstract
Basement membranes can be a barrier to tumour growth, but basement membrane molecules, including laminins, are also important autocrine factors produced by cancers to promote tumorigenesis. Many studies have shown the importance of laminin 332 (previously known as laminin 5) in this process, especially in squamous cell carcinoma. Through interactions with several cell-surface receptors (including alpha6beta4 and alpha3beta1 integrins, epidermal growth factor receptor and syndecan 1) and other basement membrane components (including type VII collagen), laminin 332 drives tumorigenesis through phosphatidylinositol-3 kinase (PI3K) and RAC1 activation, promoting tumour invasion and cell survival. The extracellular interactions of laminin 332 appear amenable to antibody-mediated therapies.
Similar articles
-
Laminin-332 and -511 in skin.Exp Dermatol. 2008 Jun;17(6):473-80. doi: 10.1111/j.1600-0625.2008.00721.x. Exp Dermatol. 2008. PMID: 18474082 Review.
-
A laminin-collagen complex drives human epidermal carcinogenesis through phosphoinositol-3-kinase activation.Cancer Res. 2007 May 1;67(9):4264-70. doi: 10.1158/0008-5472.CAN-06-4141. Cancer Res. 2007. PMID: 17483338
-
Contribution of alpha2beta1, alpha3beta1, alpha6beta4 integrins and 67 kDa laminin receptor to the interaction of epidermoid carcinoma A-431 cells with laminin-2/4.Cell Biol Int. 2006 Oct;30(10):784-92. doi: 10.1016/j.cellbi.2006.06.012. Epub 2006 Jul 7. Cell Biol Int. 2006. PMID: 16891133
-
Functional sites in the laminin alpha chains.Connect Tissue Res. 2005;46(3):142-52. doi: 10.1080/03008200591008527. Connect Tissue Res. 2005. PMID: 16147852 Review.
-
Cyclic peptides from the loop region of the laminin alpha 4 chain LG4 module show enhanced biological activity over linear peptides.Biochemistry. 2004 Oct 26;43(42):13590-7. doi: 10.1021/bi049009u. Biochemistry. 2004. PMID: 15491165
Cited by
-
Subpopulation commensalism promotes Rac1-dependent invasion of single cells via laminin-332.J Cell Biol. 2024 Jun 3;223(6):e202308080. doi: 10.1083/jcb.202308080. Epub 2024 Mar 29. J Cell Biol. 2024. PMID: 38551497
-
Lentiviral expression of wild-type LAMA3A restores cell adhesion in airway basal cells from children with epidermolysis bullosa.Mol Ther. 2024 May 1;32(5):1497-1509. doi: 10.1016/j.ymthe.2024.02.032. Epub 2024 Feb 29. Mol Ther. 2024. PMID: 38429928
-
Inhibition of TGF-β signaling, invasion, and growth of cutaneous squamous cell carcinoma by PLX8394.Oncogene. 2023 Dec;42(49):3633-3647. doi: 10.1038/s41388-023-02863-8. Epub 2023 Oct 20. Oncogene. 2023. PMID: 37864034 Free PMC article.
-
Exploring Applications of Flexible Vesicular Systems as Transdermal Drug Delivery.Curr Drug Deliv. 2024;21(8):1062-1072. doi: 10.2174/1567201821666230830125253. Curr Drug Deliv. 2024. PMID: 37649297 Review.
-
Autoimmunity against laminin 332.Front Immunol. 2023 Aug 10;14:1250115. doi: 10.3389/fimmu.2023.1250115. eCollection 2023. Front Immunol. 2023. PMID: 37638011 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials