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Review
. 2007 Aug;117(8):2044-50.
doi: 10.1172/JCI32810.

Stem cells in prostate cancer initiation and progression

Devon A Lawson  1 , Owen N Witte
Affiliations
Review

Stem cells in prostate cancer initiation and progression

Devon A Lawson et al. J Clin Invest. 2007 Aug.

Abstract

Peter Nowell and David Hungerford's discovery of the Philadelphia chromosome facilitated many critical studies that have led to a paradigm shift in our understanding of cancer as a disease of stem cells. This Review focuses on the application of these concepts to investigation of the role of stem cells in prostate cancer initiation and progression. Major strides in the development of in vitro and in vivo assays have enabled identification and characterization of prostate stem cells as well as functional evaluation of the tumorigenic effects of prostate cancer-related genetic alterations.

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Figures

Figure 1
Figure 1. Models of prostate epithelial cell differentiation.
In traditional linear hierarchy models, self-renewing PSCs residing in the basal cell (BC) layer give rise to transit-amplifying cells (TACs) of intermediate phenotypes that may express both basal and luminal cell markers during their maturation. These cells theoretically possess transient self-renewal activity and produce large numbers of terminally differentiated secretory luminal cells (LCs). In bifurcated models, basal cells and luminal cells represent separate epithelial cell lineages. These lineages may be sustained by intermediate transit-amplifying cells and/or lineage-restricted basal and luminal cell progenitors (BP and LP, respectively).
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