Diabetes provides an unfavorable environment for muscle mass and function after muscle injury in mice
- PMID: 17890896
- DOI: 10.1159/000105812
Diabetes provides an unfavorable environment for muscle mass and function after muscle injury in mice
Abstract
It is of common knowledge that diabetes decreases skeletal muscle contractility and induces atrophy. However, how hyperglycemia and insulin deficiency modify muscle mass and neuromuscular recovery after muscle injury is not well known. We have analyzed two models of diabetes: streptozotocin (STZ)-treated Swiss mice and Akita mice that spontaneously develop diabetes. A fast muscle, the tibialis anterior, was injured following injection of a myotoxic agent (cardiotoxin). Neuromuscular function was evaluated by examining in situ isometric contractile properties of regenerating muscles in response to nerve stimulation 14, 28 and 56 days after myotoxic injury. We found that STZ-induced diabetes reduces muscle weight and absolute maximal tetanic force in both regenerating and uninjured muscles (p = 0.0001). Moreover, it increases specific maximal tetanic force and tetanic fusion in regenerating and uninjured muscles (p = 0.04). In the Akita mice, diabetes decreases muscle weight and absolute maximal tetanic force, and increases tetanic fusion in both regenerating and uninjured muscles (p < or = 0.003). Interestingly, STZ-induced diabetes exerts more marked effects than diabetes of genetic origin, in particular on muscle weight. This reduction in muscle mass was not due to an increased expression of the atrogenes MuRF1 and atrogin-1 during STZ-induced diabetes. The present study in mice demonstrates that both models of diabetes impair regenerating muscles as well as uninjured muscles. Regenerating fast muscles are weaker, lighter and slower in diabetic compared with nondiabetic mice.
Copyright 2007 S. Karger AG, Basel.
Similar articles
-
Effects of mesenchymal stromal cells on type 1 diabetes mellitus rat muscles.Muscle Nerve. 2018 Oct;58(4):583-591. doi: 10.1002/mus.26196. Epub 2018 Sep 12. Muscle Nerve. 2018. PMID: 30028527
-
Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1.Nutrients. 2017 Sep 20;9(9):1040. doi: 10.3390/nu9091040. Nutrients. 2017. PMID: 28930190 Free PMC article.
-
Dysregulation between TRIM63/FBXO32 expression and soleus muscle wasting in diabetic rats: potential role of miR-1-3p, -29a/b-3p, and -133a/b-3p.Mol Cell Biochem. 2017 Mar;427(1-2):187-199. doi: 10.1007/s11010-016-2910-z. Epub 2016 Dec 20. Mol Cell Biochem. 2017. PMID: 28000044
-
Masticatory muscles of mouse do not undergo atrophy in space.FASEB J. 2015 Jul;29(7):2769-79. doi: 10.1096/fj.14-267336. Epub 2015 Mar 20. FASEB J. 2015. PMID: 25795455 Free PMC article.
-
Diabetic myopathy differs between Ins2Akita+/- and streptozotocin-induced Type 1 diabetic models.J Appl Physiol (1985). 2009 May;106(5):1650-9. doi: 10.1152/japplphysiol.91565.2008. Epub 2009 Feb 26. J Appl Physiol (1985). 2009. PMID: 19246652
Cited by
-
Pharmacologic Inhibition of Myostatin With a Myostatin Antibody Improves the Skeletal Muscle and Bone Phenotype of Male Insulin-Deficient Diabetic Mice.JBMR Plus. 2023 Oct 26;7(11):e10833. doi: 10.1002/jbm4.10833. eCollection 2023 Nov. JBMR Plus. 2023. PMID: 38025035 Free PMC article.
-
Efficiency of Biobran/MGN-3, an Arabinoxylan Rice Bran, in Attenuating Diabetes-Induced Cognitive Impairment of the Hippocampus via Oxidative Stress and IR/Akt/NF-κB in Rats.Evid Based Complement Alternat Med. 2023 Jul 19;2023:8248576. doi: 10.1155/2023/8248576. eCollection 2023. Evid Based Complement Alternat Med. 2023. PMID: 37501860 Free PMC article.
-
Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles.Nat Commun. 2023 May 22;14(1):2900. doi: 10.1038/s41467-023-38624-0. Nat Commun. 2023. PMID: 37217480 Free PMC article.
-
Muscle-specific deletion of Arid5b causes metabolic changes in skeletal muscle that affect adipose tissue and liver.Front Endocrinol (Lausanne). 2023 Jan 18;13:1083311. doi: 10.3389/fendo.2022.1083311. eCollection 2022. Front Endocrinol (Lausanne). 2023. PMID: 36743919 Free PMC article.
-
Hyperglycemia Negatively Affects IPSC-Derived Myoblast Proliferation and Skeletal Muscle Regeneration and Function.Cells. 2022 Nov 18;11(22):3674. doi: 10.3390/cells11223674. Cells. 2022. PMID: 36429100 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical