Hypoxia-inducible factors Per/ARNT/Sim domains: structure and function
- PMID: 17998046
- DOI: 10.1016/S0076-6879(07)35001-5
Hypoxia-inducible factors Per/ARNT/Sim domains: structure and function
Abstract
Hypoxia-inducible factors (HIFs) are key transcriptional regulators of genes involved in cellular adaptation to reduced oxygen availability through effects on anaerobic metabolism, oxygen delivery, angiogenesis, and cellular survival and proliferation. As such, HIFs contribute to the pathogenesis of diseases in which oxygen availability is compromised, notably ischemia and tumorigenesis. Though tremendous progress has been made in elucidating the mechanisms underlying O(2)-dependent regulation of HIF by Fe(II)- and 2-oxoglutarate-dependent dioxygenases, HIF induction can be uncoupled from these modes of regulation in diseases such as cancer. Consequently, renewed interest has developed in understanding the structure/function relationships of individual P(er)/ARNT/S(im) (PAS) domains that are important for maintaining transcriptionally active HIF complexes, regardless of the manner by which HIF is induced. This review highlights strategies for the biophysical and biochemical characterization of the PAS domains found within both HIF subunits and provides a platform for future efforts to exploit these domains in therapeutic settings.
Similar articles
-
Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B.Proc Natl Acad Sci U S A. 2011 May 10;108(19):7739-44. doi: 10.1073/pnas.1101357108. Epub 2011 Apr 21. Proc Natl Acad Sci U S A. 2011. PMID: 21512126 Free PMC article.
-
Regulation of hypoxia inducible factors (HIF) in hypoxia and normoxia during placental development.Placenta. 2010 Nov;31(11):951-7. doi: 10.1016/j.placenta.2010.08.008. Epub 2010 Sep 24. Placenta. 2010. PMID: 20869770 Review.
-
Molecular imaging: into in vivo interaction of HIF-1alpha and HIF-2alpha with ARNT.Ann N Y Acad Sci. 2009 Oct;1177:74-81. doi: 10.1111/j.1749-6632.2009.05029.x. Ann N Y Acad Sci. 2009. PMID: 19845609
-
[HIF-1 activation during tumor progression: implications and consequences].Bull Cancer. 2006 Apr;93(4):349-56. Bull Cancer. 2006. PMID: 16627239 Review. French.
-
Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.J Mol Biol. 2005 Oct 28;353(3):664-77. doi: 10.1016/j.jmb.2005.08.043. Epub 2005 Sep 6. J Mol Biol. 2005. PMID: 16181639
Cited by
-
HIF-1α Is a Rational Target for Future Ovarian Cancer Therapies.Front Oncol. 2021 Dec 24;11:785111. doi: 10.3389/fonc.2021.785111. eCollection 2021. Front Oncol. 2021. PMID: 35004308 Free PMC article. Review.
-
Intrabody Targeting HIF-1α Mediates Transcriptional Downregulation of Target Genes Related to Solid Tumors.Int J Mol Sci. 2021 Nov 15;22(22):12335. doi: 10.3390/ijms222212335. Int J Mol Sci. 2021. PMID: 34830219 Free PMC article.
-
Aryl Sulfonamides Induce Degradation of Aryl Hydrocarbon Receptor Nuclear Translocator through CRL4DCAF15 E3 Ligase.Mol Cells. 2020 Nov 30;43(11):935-944. doi: 10.14348/molcells.2020.0122. Mol Cells. 2020. PMID: 33168788 Free PMC article.
-
Iron metabolic pathways in the processes of sponge plasticity.PLoS One. 2020 Feb 21;15(2):e0228722. doi: 10.1371/journal.pone.0228722. eCollection 2020. PLoS One. 2020. PMID: 32084159 Free PMC article.
-
Identification, Characterization, and Diel Pattern of Expression of Canonical Clock Genes in Nephrops norvegicus (Crustacea: Decapoda) Eyestalk.PLoS One. 2015 Nov 2;10(11):e0141893. doi: 10.1371/journal.pone.0141893. eCollection 2015. PLoS One. 2015. PMID: 26524198 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials