Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures
- PMID: 18039125
- DOI: 10.1146/annurev.pathmechdis.3.121806.151526
Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures
Abstract
Three-dimensional (3D) epithelial culture systems recreate the cardinal features of glandular epithelium in vivo and represent a valuable tool for modeling breast cancer initiation and progression in a structurally appropriate context. 3D models have emerged as a powerful method to interrogate the biological activities of cancer genes and oncogenic pathways, and recent studies have poignantly illustrated their utility in dissecting the emerging role of tensional force in regulating epithelial tissue homeostasis. We review how 3D models are being used to investigate fundamental cellular and biophysical mechanisms associated with breast cancer progression that have not been readily amenable to traditional genetic or biochemical analysis.
Similar articles
-
Modeling breast acini in tissue culture for detection of malignant phenotype reversion to non-malignant phenotype.Iran Biomed J. 2009 Oct;13(4):191-8. Iran Biomed J. 2009. PMID: 19946344
-
In search of a stem cell hierarchy in the human breast and its relevance to breast cancer evolution.APMIS. 2005 Nov-Dec;113(11-12):903-21. doi: 10.1111/j.1600-0463.2005.apm_344.x. APMIS. 2005. PMID: 16480457 Review.
-
Modelling glandular epithelial cancers in three-dimensional cultures.Nat Rev Cancer. 2005 Sep;5(9):675-88. doi: 10.1038/nrc1695. Nat Rev Cancer. 2005. PMID: 16148884 Review.
-
Interaction with endothelial cells is a prerequisite for branching ductal-alveolar morphogenesis and hyperplasia of preneoplastic human breast epithelial cells: regulation by estrogen.Cancer Res. 2000 Jan 15;60(2):439-49. Cancer Res. 2000. PMID: 10667599
-
Human models of breast cancer.Cancer Surv. 1993;16:59-78. Cancer Surv. 1993. PMID: 8348539 Review.
Cited by
-
From Microspikes to Stress Fibers: Actin Remodeling in Breast Acini Drives Myosin II-Mediated Basement Membrane Invasion.Cells. 2021 Aug 4;10(8):1979. doi: 10.3390/cells10081979. Cells. 2021. PMID: 34440749 Free PMC article.
-
Sprouty4 negatively regulates ERK/MAPK signaling and the transition from in situ to invasive breast ductal carcinoma.PLoS One. 2021 May 28;16(5):e0252314. doi: 10.1371/journal.pone.0252314. eCollection 2021. PLoS One. 2021. PMID: 34048471 Free PMC article.
-
Cell Force-Driven Basement Membrane Disruption Fuels EGF- and Stiffness-Induced Invasive Cell Dissemination from Benign Breast Gland Acini.Int J Mol Sci. 2021 Apr 12;22(8):3962. doi: 10.3390/ijms22083962. Int J Mol Sci. 2021. PMID: 33921304 Free PMC article.
-
Cell death pathways and viruses: Role of microRNAs.Mol Ther Nucleic Acids. 2021 Mar 19;24:487-511. doi: 10.1016/j.omtn.2021.03.011. eCollection 2021 Jun 4. Mol Ther Nucleic Acids. 2021. PMID: 33898103 Free PMC article. Review.
-
The Tumor Microenvironment of Primitive and Metastatic Breast Cancer: Implications for Novel Therapeutic Strategies.Int J Mol Sci. 2020 Oct 30;21(21):8102. doi: 10.3390/ijms21218102. Int J Mol Sci. 2020. PMID: 33143050 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical