Mechanisms of inhibition in cat visual cortex
- PMID: 1804983
- PMCID: PMC1180175
- DOI: 10.1113/jphysiol.1991.sp018731
Mechanisms of inhibition in cat visual cortex
Abstract
1. Neurones from layers 2-6 of the cat primary visual cortex were studied using extracellular and intracellular recordings made in vivo. The aim was to identify inhibitory events and determine whether they were associated with small or large (shunting) changes in the input conductance of the neurones. 2. Visual stimulation of subfields of simple receptive fields produced depolarizing or hyperpolarizing potentials that were associated with increased or decreased firing rates respectively. Hyperpolarizing potentials were small, 5 mV or less. In the same neurones, brief electrical stimulation of cortical afferents produced a characteristic sequence of a brief depolarization followed by a long-lasting (200-400 ms) hyperpolarization. 3. During the response to a stationary flashed bar, the synaptic activation increased the input conductance of the neurone by about 5-20%. Conductance changes of similar magnitude were obtained by electrically stimulating the neurone. Neurones stimulated with non-optimal orientations or directions of motion showed little change in input conductance. 4. These data indicate that while visually or electrically induced inhibition can be readily demonstrated in visual cortex, the inhibition is not associated with large sustained conductance changes. Thus a shunting or multiplicative inhibitory mechanism is not the principal mechanism of inhibition.
Similar articles
-
An intracellular analysis of the visual responses of neurones in cat visual cortex.J Physiol. 1991;440:659-96. doi: 10.1113/jphysiol.1991.sp018730. J Physiol. 1991. PMID: 1804981 Free PMC article.
-
Stimulus-selective spiking is driven by the relative timing of synchronous excitation and disinhibition in cat striate neurons in vivo.Eur J Neurosci. 2008 Oct;28(7):1286-300. doi: 10.1111/j.1460-9568.2008.06434.x. Eur J Neurosci. 2008. PMID: 18973556
-
Two inhibitory postsynaptic potentials, and GABAA and GABAB receptor-mediated responses in neocortex of rat and cat.J Physiol. 1988 Dec;406:443-68. doi: 10.1113/jphysiol.1988.sp017390. J Physiol. 1988. PMID: 2855437 Free PMC article.
-
Visual input evokes transient and strong shunting inhibition in visual cortical neurons.Nature. 1998 May 28;393(6683):369-73. doi: 10.1038/30735. Nature. 1998. PMID: 9620800
-
Temporal covariance of postsynaptic membrane potential and synaptic input--role in synaptic efficacy in visual cortex.Prog Brain Res. 1993;95:207-23. doi: 10.1016/s0079-6123(08)60370-2. Prog Brain Res. 1993. PMID: 8493334 Review. No abstract available.
Cited by
-
Emergence of task-related spatiotemporal population dynamics in transplanted neurons.Nat Commun. 2023 Nov 11;14(1):7320. doi: 10.1038/s41467-023-43081-w. Nat Commun. 2023. PMID: 37951968 Free PMC article.
-
ERAASR: an algorithm for removing electrical stimulation artifacts from multielectrode array recordings.J Neural Eng. 2018 Apr;15(2):026020. doi: 10.1088/1741-2552/aaa365. J Neural Eng. 2018. PMID: 29265009 Free PMC article.
-
Feedforward origins of response variability underlying contrast invariant orientation tuning in cat visual cortex.Neuron. 2012 Jun 7;74(5):911-23. doi: 10.1016/j.neuron.2012.05.007. Neuron. 2012. PMID: 22681694 Free PMC article.
-
Insights into cortical mechanisms of behavior from microstimulation experiments.Prog Neurobiol. 2013 Apr;103:115-30. doi: 10.1016/j.pneurobio.2012.01.006. Epub 2012 Jan 28. Prog Neurobiol. 2013. PMID: 22307059 Free PMC article. Review.
-
Direct electrical stimulation of human cortex - the gold standard for mapping brain functions?Nat Rev Neurosci. 2011 Nov 30;13(1):63-70. doi: 10.1038/nrn3140. Nat Rev Neurosci. 2011. PMID: 22127300 Review.
References
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous