Review
doi: 10.1016/j.cmet.2007.12.009.
Selective versus total insulin resistance: a pathogenic paradox
Affiliations
- PMID: 18249166
- DOI: 10.1016/j.cmet.2007.12.009
Item in Clipboard
Review
Selective versus total insulin resistance: a pathogenic paradox
Cell Metab.
2008 Feb.
Free article
Abstract
Mice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly combination of hyperglycemia and hypertriglyceridemia. In this issue of Cell Metabolism, Biddinger et al. (2008) show that mice with total hepatic insulin resistance exhibit hyperglycemia without hypertriglyceridemia-a state paradoxically less severe than selective insulin resistance.
Comment on
-
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.Cell Metab. 2008 Feb;7(2):125-34. doi: 10.1016/j.cmet.2007.11.013. Cell Metab. 2008. PMID: 18249172 Free PMC article.
Similar articles
-
Long Noncoding RNA lncSHGL Recruits hnRNPA1 to Suppress Hepatic Gluconeogenesis and Lipogenesis.Diabetes. 2018 Apr;67(4):581-593. doi: 10.2337/db17-0799. Epub 2018 Jan 30. Diabetes. 2018. PMID: 29382663
-
Insulin regulation of gluconeogenesis.Ann N Y Acad Sci. 2018 Jan;1411(1):21-35. doi: 10.1111/nyas.13435. Epub 2017 Sep 3. Ann N Y Acad Sci. 2018. PMID: 28868790 Free PMC article. Review.
-
Unraveling the Regulation of Hepatic Metabolism by Insulin.Trends Endocrinol Metab. 2017 Jul;28(7):497-505. doi: 10.1016/j.tem.2017.03.003. Epub 2017 Apr 14. Trends Endocrinol Metab. 2017. PMID: 28416361 Free PMC article. Review.
-
Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity.Nat Commun. 2016 Oct 6;7:12977. doi: 10.1038/ncomms12977. Nat Commun. 2016. PMID: 27708333 Free PMC article.
-
FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis.Hepatology. 2014 May;59(5):1779-90. doi: 10.1002/hep.26945. Epub 2014 Mar 27. Hepatology. 2014. PMID: 24806753
Cited by
-
Gut microbiome is associated with personality traits of free-ranging Tibetan macaques (Macaca thibetana).Front Microbiol. 2024 Apr 22;15:1381372. doi: 10.3389/fmicb.2024.1381372. eCollection 2024. Front Microbiol. 2024. PMID: 38711972 Free PMC article.
-
Regulated regeneration of adipose tissue in lipodystrophic Agpat2-null mice partially ameliorates hepatic steatosis.iScience. 2024 Mar 26;27(4):109517. doi: 10.1016/j.isci.2024.109517. eCollection 2024 Apr 19. iScience. 2024. PMID: 38623324 Free PMC article.
-
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review).Mol Med Rep. 2024 Jun;29(6):95. doi: 10.3892/mmr.2024.13219. Epub 2024 Apr 12. Mol Med Rep. 2024. PMID: 38606791 Free PMC article. Review.
-
Hepatic insulin resistance and muscle insulin resistance are characterized by distinct postprandial plasma metabolite profiles: a cross-sectional study.Cardiovasc Diabetol. 2024 Mar 16;23(1):97. doi: 10.1186/s12933-024-02188-0. Cardiovasc Diabetol. 2024. PMID: 38493102 Free PMC article.
-
Advances in free fatty acid profiles in gestational diabetes mellitus.J Transl Med. 2024 Feb 19;22(1):180. doi: 10.1186/s12967-024-04922-4. J Transl Med. 2024. PMID: 38374136 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
