'Mendelian randomization' equals instrumental variable analysis with genetic instruments
- PMID: 18344186
- PMCID: PMC2706420
- DOI: 10.1002/sim.3255
'Mendelian randomization' equals instrumental variable analysis with genetic instruments
Abstract
Interest in instrumental variable (IV) analyses using genetic instruments has been growing over the past 4 years. The background, strength and weaknesses of this approach, which in the epidemiology literature has been referred to as 'Mendelian randomization', has been recently reviewed by Lawlor et al. (Statist. Med. 2007. DOI: 10.1002/sim.3034). We suggest a change in the nomenclature of 'Mendelian randomization' and discuss issues relevant to IV analysis including instrument validation, motivation of IV analysis and interpretation of IV estimates in order to motivate a more consistent and standard use of IV analysis across applications using genetic instruments.
(c) 2008 John Wiley & Sons, Ltd.
Comment in
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Is Mendelian randomization 'lost in translation?': comments on 'Mendelian randomization equals instrumental variable analysis with genetic instruments' by Wehby et al.Stat Med. 2008 Jul 10;27(15):2750-5. doi: 10.1002/sim.3308. Stat Med. 2008. PMID: 18509868 No abstract available.
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