[Chemotherapy for pancreatic cancer]
- PMID: 18349573
[Chemotherapy for pancreatic cancer]
Abstract
Chemotherapy is expected to play an important role in the treatment of pancreatic cancer because most of pancreatic cancers are being discovered at locally advanced or metastatic stages and recurrence rate is high even after the curative resection. Gemcitabine is a key agent for the first-line therapy of advanced pancreatic cancer. It can enhance the quality of life and prolong the survival of patients. Combination of erlotinib or capecitabine with gemcitabine showed a marginal survival benefit over single-agent gemcitabine. If patient's performance state is good, gemcitabine-based platinum combination therapy showed overall survival benefit compared with gemcitabine monothrapy. If the first-line palliative chemotherapy fails, 5-FU, capcitabine, or tegafur with or without combination can be used as the second-line agents. Adjuvant chemotherapy using 5-FU or gemcitabine after curative resection has overall survival benefit. However, neoadjuvant chemotherapy has not been proven to be effective in the treatment of pancreatic cancer.
Similar articles
-
Prospective efficacy and safety study of neoadjuvant gemcitabine with capecitabine combination chemotherapy for borderline-resectable or unresectable locally advanced pancreatic adenocarcinoma.Surgery. 2012 Nov;152(5):851-62. doi: 10.1016/j.surg.2012.03.010. Epub 2012 Jun 6. Surgery. 2012. PMID: 22682078 Clinical Trial.
-
Developments in metastatic pancreatic cancer: is gemcitabine still the standard?World J Gastroenterol. 2012 Feb 28;18(8):736-45. doi: 10.3748/wjg.v18.i8.736. World J Gastroenterol. 2012. PMID: 22371633 Free PMC article. Review.
-
Long-term results of full-dose gemcitabine with radiation therapy compared to 5-fluorouracil with radiation therapy for locally advanced pancreas cancer.Radiother Oncol. 2011 May;99(2):114-9. doi: 10.1016/j.radonc.2011.05.038. Epub 2011 May 27. Radiother Oncol. 2011. PMID: 21621866
-
Palliative chemotherapy for pancreatic malignancies.Surg Clin North Am. 2010 Apr;90(2):365-75. doi: 10.1016/j.suc.2009.12.005. Surg Clin North Am. 2010. PMID: 20362792 Review.
-
New directions in the management of advanced pancreatic cancer: a review.Anticancer Drugs. 2008 Jun;19(5):435-46. doi: 10.1097/CAD.0b013e3282fc9d11. Anticancer Drugs. 2008. PMID: 18418211 Review.
Cited by
-
Factors of Endoscopic Ultrasound-Guided Tissue Acquisition for Successful Next-Generation Sequencing in Pancreatic Ductal Adenocarcinoma.Gut Liver. 2020 May 15;14(3):387-394. doi: 10.5009/gnl19011. Gut Liver. 2020. PMID: 31581388 Free PMC article.
-
Effect of quercetin on apoptosis of PANC-1 cells.J Korean Surg Soc. 2013 Dec;85(6):249-60. doi: 10.4174/jkss.2013.85.6.249. Epub 2013 Nov 26. J Korean Surg Soc. 2013. PMID: 24368982 Free PMC article.
