Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease
- PMID: 1840078
- DOI: 10.1016/0304-3940(91)90583-f
Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease
Abstract
Neuronal loss in the cerebral cortex in Huntington's disease (HD) has not been well documented, nor has its laminar pattern been definitively established. We therefore counted neurons in individual cortical laminae in the dorsal frontal cortex of 5 HD and 5 control autopsy brains. Significant neuronal loss (to 57% of control, P = 0.002) was found in layer VI of HD brains. These cells project principally to the thalamus, the claustrum and other regions of cerebral cortex; thus their loss is unlikely to be the result of retrograde degeneration secondary to striatal pathology. Layer V neurons were also decreased (to 71% of control, P = 0.034). Degeneration of cerebral cortical neurons may be at least partly responsible for some of the non-choreic symptoms of HD, such as dementia, irritability, apathy, and depression.
Similar articles
-
Molecular insights into cortico-striatal miscommunications in Huntington's disease.Curr Opin Neurobiol. 2018 Feb;48:79-89. doi: 10.1016/j.conb.2017.10.019. Epub 2017 Nov 7. Curr Opin Neurobiol. 2018. PMID: 29125980 Free PMC article. Review.
-
The Neuropathology of Huntington's Disease.Curr Top Behav Neurosci. 2015;22:33-80. doi: 10.1007/7854_2014_354. Curr Top Behav Neurosci. 2015. PMID: 25300927 Review.
-
Widespread heterogeneous neuronal loss across the cerebral cortex in Huntington's disease.J Huntingtons Dis. 2014;3(1):45-64. doi: 10.3233/JHD-140092. J Huntingtons Dis. 2014. PMID: 25062764
-
Evidence for progression in frontal cortical pathology in late-stage Huntington's disease.J Comp Neurol. 2004 Jan 6;468(2):190-204. doi: 10.1002/cne.10938. J Comp Neurol. 2004. PMID: 14648679
-
Morphometric analysis of the prefrontal cortex in Huntington's disease.Neurology. 1991 Jul;41(7):1117-23. doi: 10.1212/wnl.41.7.1117. Neurology. 1991. PMID: 1829794
Cited by
-
Nebulization of low-dose aspirin ameliorates Huntington's pathology in N171-82Q transgenic mice.NeuroImmune Pharm Ther. 2024 Feb 9;3(1):47-59. doi: 10.1515/nipt-2023-0026. eCollection 2024 Mar. NeuroImmune Pharm Ther. 2024. PMID: 38532785 Free PMC article.
-
Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity.Brain Commun. 2022 Nov 25;4(6):fcac309. doi: 10.1093/braincomms/fcac309. eCollection 2022. Brain Commun. 2022. PMID: 36523269 Free PMC article.
-
Comprehensive shape analysis of the cortex in Huntington's disease.Hum Brain Mapp. 2023 Mar;44(4):1417-1431. doi: 10.1002/hbm.26125. Epub 2022 Nov 21. Hum Brain Mapp. 2023. PMID: 36409662 Free PMC article.
-
Role of DNMTs in the Brain.Adv Exp Med Biol. 2022;1389:363-394. doi: 10.1007/978-3-031-11454-0_15. Adv Exp Med Biol. 2022. PMID: 36350518 Review.
-
Neurofilament light-associated connectivity in young-adult Huntington's disease is related to neuronal genes.Brain. 2022 Nov 21;145(11):3953-3967. doi: 10.1093/brain/awac227. Brain. 2022. PMID: 35758263 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical