Dkk1 and Wnt3 interact to control head morphogenesis in the mouse
- PMID: 18403408
- DOI: 10.1242/dev.018853
Dkk1 and Wnt3 interact to control head morphogenesis in the mouse
Abstract
Loss of Dkk1 results in ectopic WNT/beta-catenin signalling activity in the anterior germ layer tissues and impairs cell movement in the endoderm of the mouse gastrula. The juxtaposition of the expression domains of Dkk1 and Wnt3 is suggestive of an antagonist-agonist interaction. The downregulation of Dkk1 when Wnt3 activity is reduced reveals a feedback mechanism for regulating WNT signalling. Compound Dkk1;Wnt3 heterozygous mutant embryos display head truncation and trunk malformation, which are not found in either Dkk1(+/-) or Wnt3(+/-) embryos. Reducing the dose of Wnt3 gene in Dkk1(-/-) embryos partially rescues the truncated head phenotype. These findings highlight that head development is sensitive to the level of WNT3 signalling and that DKK1 is the key antagonist that modulates WNT3 activity during anterior morphogenesis.
Similar articles
-
Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm.Dev Cell. 2005 Nov;9(5):639-50. doi: 10.1016/j.devcel.2005.09.011. Dev Cell. 2005. PMID: 16256739
-
Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse.Mech Dev. 2007 Feb;124(2):157-165. doi: 10.1016/j.mod.2006.10.001. Epub 2006 Oct 10. Mech Dev. 2007. PMID: 17127040
-
Structure-based mutation analysis shows the importance of LRP5 beta-propeller 1 in modulating Dkk1-mediated inhibition of Wnt signaling.Gene. 2007 Apr 15;391(1-2):103-12. doi: 10.1016/j.gene.2006.12.014. Epub 2006 Dec 29. Gene. 2007. PMID: 17276019
-
Building the mouse gastrula: signals, asymmetry and lineages.Curr Opin Genet Dev. 2006 Aug;16(4):419-25. doi: 10.1016/j.gde.2006.06.008. Epub 2006 Jun 21. Curr Opin Genet Dev. 2006. PMID: 16793258 Review.
-
Definitive endoderm of the mouse embryo: formation, cell fates, and morphogenetic function.Dev Dyn. 2006 Sep;235(9):2315-29. doi: 10.1002/dvdy.20846. Dev Dyn. 2006. PMID: 16752393 Review.
Cited by
-
Single-Nucleotide Polymorphisms in WNT Genes in Patients with Non-Syndromic Orofacial Clefts in a Polish Population.Diagnostics (Basel). 2024 Jul 17;14(14):1537. doi: 10.3390/diagnostics14141537. Diagnostics (Basel). 2024. PMID: 39061674 Free PMC article.
-
Wnt signal-dependent antero-posterior specification of early-stage CNS primordia modeled in EpiSC-derived neural stem cells.Front Cell Dev Biol. 2024 Feb 9;11:1260528. doi: 10.3389/fcell.2023.1260528. eCollection 2023. Front Cell Dev Biol. 2024. PMID: 38405136 Free PMC article.
-
LRP5, Bone Mass Polymorphisms and Skeletal Disorders.Genes (Basel). 2023 Sep 23;14(10):1846. doi: 10.3390/genes14101846. Genes (Basel). 2023. PMID: 37895195 Free PMC article. Review.
-
Non-Specific Inhibition of Dipeptidyl Peptidases 8/9 by Dipeptidyl Peptidase 4 Inhibitors Negatively Affects Mesenchymal Stem Cell Differentiation.J Clin Med. 2023 Jul 12;12(14):4632. doi: 10.3390/jcm12144632. J Clin Med. 2023. PMID: 37510747 Free PMC article.
-
Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function.Front Cell Dev Biol. 2023 Apr 7;11:1173688. doi: 10.3389/fcell.2023.1173688. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37091972 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases