doi: 10.1016/j.febslet.2008.04.038.
Epub 2008 May 5.
FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity
Affiliations
- PMID: 18460341
- DOI: 10.1016/j.febslet.2008.04.038
Item in Clipboard
FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity
FEBS Lett.
.
Free article
Abstract
Fibroblast growth factor 21 (FGF21) is active in murine adipocytes and has beneficial metabolic effects in animal models of type 2 diabetes mellitus. We assessed whether FGF21 influences lipolysis in human adipocytes and 3T3-L1 cells. FGF21 had no short-time effect (h) while a 3-day incubation with FGF21 attenuated hormone-stimulated lipolysis. FGF21 did not influence the mRNA expression of genes involved in regulating lipolysis, but significantly reduced the expression of the lipid droplet-associated phosphoprotein perilipin without affecting differentiation. Via reduced release of fatty acids into the circulation, the anti-lipolytic effect could be a mechanism through which FGF21 promotes insulin sensitivity in man.
Similar articles
-
Curcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3T3-L1 adipocytes.Phytomedicine. 2012 Dec 15;20(1):3-8. doi: 10.1016/j.phymed.2012.09.003. Epub 2012 Oct 17. Phytomedicine. 2012. PMID: 23083815
-
Astragaloside IV attenuates lipolysis and improves insulin resistance induced by TNFalpha in 3T3-L1 adipocytes.Phytother Res. 2008 Nov;22(11):1434-9. doi: 10.1002/ptr.2434. Phytother Res. 2008. PMID: 18972582
-
[Perilipin associated with lipid droplets regulates lipolysis].Sheng Li Ke Xue Jin Zhan. 2006 Jul;37(3):221-4. Sheng Li Ke Xue Jin Zhan. 2006. PMID: 17009729 Review. Chinese.
-
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.IUBMB Life. 2004 Jul;56(7):379-85. doi: 10.1080/15216540400009968. IUBMB Life. 2004. PMID: 15545214 Review.
-
Medium-chain Fatty acids attenuate agonist-stimulated lipolysis, mimicking the effects of starvation.Obes Res. 2004 Apr;12(4):599-611. doi: 10.1038/oby.2004.69. Obes Res. 2004. PMID: 15090627
Cited by
-
Hepatokines: the missing link in the development of insulin resistance and hyperandrogenism in PCOS?Hormones (Athens). 2023 Dec;22(4):715-724. doi: 10.1007/s42000-023-00487-x. Epub 2023 Sep 14. Hormones (Athens). 2023. PMID: 37704921 Review.
-
The association of FGF-21 with the risk of newly diagnosed type-2 diabetes mellitus: a cross-sectional study in Southern China.BMC Endocr Disord. 2023 Sep 1;23(1):188. doi: 10.1186/s12902-023-01426-y. BMC Endocr Disord. 2023. PMID: 37658393 Free PMC article.
-
Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective.Genes Dis. 2022 Feb 2;10(3):825-847. doi: 10.1016/j.gendis.2021.12.011. eCollection 2023 May. Genes Dis. 2022. PMID: 37396511 Free PMC article. Review.
-
The potential effect of metformin on fibroblast growth factor 21 in type 2 diabetes mellitus (T2DM).Inflammopharmacology. 2023 Aug;31(4):1751-1760. doi: 10.1007/s10787-023-01255-4. Epub 2023 Jun 19. Inflammopharmacology. 2023. PMID: 37337094 Review.
-
Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis.Int J Mol Sci. 2023 Apr 14;24(8):7284. doi: 10.3390/ijms24087284. Int J Mol Sci. 2023. PMID: 37108444 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
