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. 2008 Sep 15;198(6):864-7.
doi: 10.1086/591184.

The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir

Sara Colombo  1 , Andri Rauch, Margalida Rotger, Jacques Fellay, Raquel Martinez, Christoph Fux, Christine Thurnheer, Huldrych F Günthard, David B Goldstein, Hansjakob Furrer, Amalio Telenti; Swiss HIV Cohort Study
Collaborators, Affiliations
Free article

The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir

Sara Colombo et al. J Infect Dis. .
Free article

Erratum in

  • J Infect Dis. 2008 Nov 1;198(9):1415

Abstract

The HLA-B 5701 allele is predictive of hypersensitivity reaction to abacavir, a response herein termed "ABC-HSR." This study of 1,103 individuals infected with human immunodeficiency virus assessed the usefulness of genotyping a HCP5 single-nucleotide polymorphism (SNP), rs2395029, in relation to ABC-HSR. In populations with European ancestry, rs2395029 is in linkage disequilibrium with HLA-B 5701. The HCP5 SNP was present in all 98 HLA-B 5701-positive individuals and was absent in 999 of 1005 HLA-B 5701-negative individuals. rs2395029 was overrepresented in 25 individuals with clinically likely ABC-HSR, compared with its frequency in 175 ABC-tolerant individuals (80% vs. 2%, respectively; P < .0001). Therefore, HCP5 genotyping could serve as a simple screening tool for ABC-HSR, particularly in settings where sequence-based HLA typing is not available.

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