Lack of endogenous TRIM5alpha-mediated restriction in rhesus macaque dendritic cells
- PMID: 18703703
- DOI: 10.1182/blood-2008-04-151761
Lack of endogenous TRIM5alpha-mediated restriction in rhesus macaque dendritic cells
Abstract
Rhesus macaques are resistant to infection by HIV-1 as a result of an innate cellular restriction mechanism attributable to the expression of rhTRIM5alpha, a member of the large tripartite motif (TRIM) protein family. TRIM5alpha-mediated restriction, which occurs before reverse transcription through targeting of the HIV-1 capsid, has been identified in a number of macaque primary cells and cell lines and is thought to occur in all macaque cell types. We report, however, that rhesus macaque dendritic cells (DCs) lack TRIM5alpha-mediated restriction and are equally permissive to HIV-1 infection as human DCs. Evidence suggests that, although TRIM5alpha RNA levels are normal in these cells, the protein may be dysfunctional. We propose that abrogation of TRIM5alpha-mediated restriction in DCs, although still operative in cells that replicate HIV-1 (macrophages, T lymphocytes), illustrates the need for innate mechanisms to not inhibit adaptive immune responses to ensure an optimal fight against pathogens.
Similar articles
-
Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor Functioning.Viruses. 2021 Feb 19;13(2):320. doi: 10.3390/v13020320. Viruses. 2021. PMID: 33669846 Free PMC article. Review.
-
K63-Linked Ubiquitin Is Required for Restriction of HIV-1 Reverse Transcription and Capsid Destabilization by Rhesus TRIM5α.J Virol. 2019 Jun 28;93(14):e00558-19. doi: 10.1128/JVI.00558-19. Print 2019 Jul 15. J Virol. 2019. PMID: 31068426 Free PMC article.
-
Human immunodeficiency virus type 1 restriction by human-rhesus chimeric tripartite motif 5alpha (TRIM 5alpha) in CD34(+) cell-derived macrophages in vitro and in T cells in vivo in severe combined immunodeficient (SCID-hu) mice transplanted with human fetal tissue.Hum Gene Ther. 2008 Mar;19(3):217-28. doi: 10.1089/hum.2007.108. Hum Gene Ther. 2008. PMID: 18279037
-
TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization.J Virol. 2015 Dec 16;90(4):1849-57. doi: 10.1128/JVI.01948-15. Print 2016 Feb 15. J Virol. 2015. PMID: 26676782 Free PMC article.
-
Impact of TRIM5α in vivo.AIDS. 2015 Sep 10;29(14):1733-43. doi: 10.1097/QAD.0000000000000812. AIDS. 2015. PMID: 26372380 Free PMC article. Review.
Cited by
-
Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor Functioning.Viruses. 2021 Feb 19;13(2):320. doi: 10.3390/v13020320. Viruses. 2021. PMID: 33669846 Free PMC article. Review.
-
The TRIMendous Role of TRIMs in Virus-Host Interactions.Vaccines (Basel). 2017 Aug 22;5(3):23. doi: 10.3390/vaccines5030023. Vaccines (Basel). 2017. PMID: 28829373 Free PMC article. Review.
-
Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells.Cell Rep. 2016 Jan 12;14(2):355-69. doi: 10.1016/j.celrep.2015.12.039. Epub 2015 Dec 31. Cell Rep. 2016. PMID: 26748714 Free PMC article.
-
TRIM5α is a SUMO substrate.Retrovirology. 2015 Mar 24;12:28. doi: 10.1186/s12977-015-0155-7. Retrovirology. 2015. PMID: 25880753 Free PMC article.
-
Suppressor of cytokine signaling 1 counteracts rhesus macaque TRIM5α-induced inhibition of human immunodeficiency virus type-1 production.PLoS One. 2014 Oct 13;9(10):e109640. doi: 10.1371/journal.pone.0109640. eCollection 2014. PLoS One. 2014. PMID: 25310711 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources