Effects of administration of a monoclonal antibody against mouse tumor necrosis factor alpha during pregnancy and lactation on the pre- and postnatal development of the mouse immune system
- PMID: 18821398
- DOI: 10.1080/10915810802368196
Effects of administration of a monoclonal antibody against mouse tumor necrosis factor alpha during pregnancy and lactation on the pre- and postnatal development of the mouse immune system
Abstract
Monoclonal antibodies directed against tumor necrosis factor alpha (TNFalpha) are currently employed in the treatment of various immune-mediated diseases. These studies were designed to evaluate potential effects of anti-TNFalpha treatment in mice during pregnancy and lactation on the development of the immune system in the F1 generation. Pregnant CD-1 mice were treated with vehicle or with 10 or 40 mg/kg of an anti-mouse TNFalpha monoclonal antibody (mAb) (cV1q) on days 6, 12, and 18 of gestation and on days 3, 9, and 15 of lactation. Evaluation of immune system functionality was conducted in F1 generation mice at 11 weeks of age. Immune function was evaluated by splenocyte phenotyping, immunoglobulin M (IgM) antibody response to sheep red blood cells (SRBCs), spleen cell proliferative response to anti-CD3, and natural killer cell activity. Treatment of pregnant mice with cV1q produced no adverse effects in the dams and no adverse effects in the F1 generation. In general, the functioning of the immune system of the F1 generation did not appear to be adversely affected following exposure to cV1q in utero and during lactation. The only statistically significant change was a slight (approximately 20%) reduction in the spleen cell expansion in response to SRBC immunization in the female F1 mice from the 40 mg/kg cV1q treatment group. In conclusion, administration of a monoclonal antibody against mouse TNFalpha during pregnancy and lactation had little or no effect on selected immune parameters in mice, with only a possible minor attenuation of spleen cell response to immunization noted in the female F1 generation at 11 weeks of age.
Similar articles
-
Developmental immunotoxicity of atrazine in rodents.Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):139-45. doi: 10.1111/j.1742-7843.2007.00175.x. Basic Clin Pharmacol Toxicol. 2008. PMID: 18226067 Review.
-
Effects of an anti-TNF-alpha monoclonal antibody, administered throughout pregnancy and lactation, on the development of the macaque immune system.Am J Reprod Immunol. 2007 Aug;58(2):138-49. doi: 10.1111/j.1600-0897.2007.00499.x. Am J Reprod Immunol. 2007. PMID: 17631007
-
Immune system development in the dog and cat.J Comp Pathol. 2007 Jul;137 Suppl 1:S10-5. doi: 10.1016/j.jcpa.2007.04.005. Epub 2007 Jun 8. J Comp Pathol. 2007. PMID: 17560591 Review.
-
A T-cell-dependent humoral immune response is preserved during the administration of the nerve agent pre-treatment pyridostigmine bromide in a murine model.Int Immunopharmacol. 2005 Mar;5(3):525-40. doi: 10.1016/j.intimp.2004.10.014. Int Immunopharmacol. 2005. PMID: 15683849
-
Dietary methoxychlor exposure modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in F0 and F1 generations of Sprague Dawley rats.Toxicology. 2005 Feb 14;207(2):271-81. doi: 10.1016/j.tox.2004.09.011. Toxicology. 2005. PMID: 15596257
Cited by
-
Biologics During Pregnancy and Breastfeeding Among Women With Rheumatic Diseases: Safety Clinical Evidence on the Road.Front Pharmacol. 2021 Feb 11;12:621247. doi: 10.3389/fphar.2021.621247. eCollection 2021. Front Pharmacol. 2021. PMID: 34122062 Free PMC article. Review.
-
Concordance of preclinical and clinical pharmacology and toxicology of monoclonal antibodies and fusion proteins: soluble targets.Br J Pharmacol. 2012 Jun;166(3):806-22. doi: 10.1111/j.1476-5381.2011.01812.x. Br J Pharmacol. 2012. PMID: 22168335 Free PMC article. Review.
-
Rheumatoid arthritis and pregnancy: evolution of disease activity and pathophysiological considerations for drug use.Rheumatology (Oxford). 2011 Nov;50(11):1955-68. doi: 10.1093/rheumatology/ker302. Epub 2011 Sep 2. Rheumatology (Oxford). 2011. PMID: 21890617 Free PMC article. Review.
-
[Biologics during pregnancy and breast--feeding].Z Rheumatol. 2010 Nov;69(9):780-7. doi: 10.1007/s00393-010-0640-2. Z Rheumatol. 2010. PMID: 21063826 Review. German.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical