Chemical compositions responsible for inflammation and tissue damage in the mouse lung by coarse and fine particulate samples from contrasting air pollution in Europe
- PMID: 18855153
- DOI: 10.1080/08958370802147282
Chemical compositions responsible for inflammation and tissue damage in the mouse lung by coarse and fine particulate samples from contrasting air pollution in Europe
Abstract
Inflammation is regarded as an important mechanism in mortality and morbidity associated with exposures of cardiorespiratory patients to urban air particulate matter. We investigated the association of the chemical composition and sources of urban air fine (PM(2.5-0.2)) and coarse (PM(10-2.5)) particulate samples with the inflammatory activity in the mouse lung. The particulate samples were collected during selected seasons in six European cities using a high-volume cascade impactor. Healthy C57BL/6J mice were intratracheally instilled with a single dose (10 mg/kg) of the particulate samples. At 4, 12, and 24 h after the exposure, the lungs were lavaged and the bronchoalveolar lavage fluid (BALF) was assayed for indicators of inflammation and tissue damage: cell number, total protein, and cytokines (tumor necrosis factor [TNF]-alpha, interleukin [IL]-6, and KC). Dicarboxylic acids and transition metals, especially Ni and V, in PM(2.5-0.2) correlated positively and some secondary inorganic ions (NO3(-), NH4(+)) negatively with the inflammatory activity. Total organic matter and SO4(2-) had no consistent correlations. In addition, the soil-derived constituents (Ca2+, Al, Fe, Si) showed positive correlations with the PM(2.5-0.2)-induced inflammatory activity, but their role in PM(10-2.5) remained obscure, possibly due to largely undefined biogenic material. Markers of poor biomass and coal combustion, i.e., monosaccharide anhydrides and As, were associated with elevated PAH contents in PM(2.5-0.2) and a consistent immunosuppressive effect. Overall, our results support epidemiological findings that the local sources of incomplete combustion and resuspended road dust are important in urban air particulate pollution-related health effects.
Similar articles
-
Inflammation and tissue damage in mouse lung by single and repeated dosing of urban air coarse and fine particles collected from six European cities.Inhal Toxicol. 2010 Apr;22(5):402-16. doi: 10.3109/08958370903527908. Inhal Toxicol. 2010. PMID: 20121583
-
Seasonal variation in chemical composition of size-segregated urban air particles and the inflammatory activity in the mouse lung.Inhal Toxicol. 2010 Jan;22(1):17-32. doi: 10.3109/08958370902862426. Inhal Toxicol. 2010. PMID: 20017591
-
Associations of urban air particulate composition with inflammatory and cytotoxic responses in RAW 246.7 cell line.Inhal Toxicol. 2009 Oct;21(12):994-1006. doi: 10.1080/08958370802695710. Inhal Toxicol. 2009. PMID: 19772479
-
Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms.J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Oct-Dec;26(4):339-62. doi: 10.1080/10590500802494538. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008. PMID: 19034792 Review.
-
Air pollution combustion emissions: characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects.Mutat Res. 2007 Nov-Dec;636(1-3):95-133. doi: 10.1016/j.mrrev.2007.08.003. Epub 2007 Aug 17. Mutat Res. 2007. PMID: 17951105 Review.
Cited by
-
A cohort study of the multipollutant effects of PM2.5, NO2, and O3 on C-reactive protein levels during pregnancy.Environ Epidemiol. 2024 May 6;8(3):e308. doi: 10.1097/EE9.0000000000000308. eCollection 2024 Jun. Environ Epidemiol. 2024. PMID: 38799262 Free PMC article.
-
Long-term Exposure to Ambient PM2.5 and Its Components Associated With Diabetes: Evidence From a Large Population-Based Cohort From China.Diabetes Care. 2023 Jan 1;46(1):111-119. doi: 10.2337/dc22-1585. Diabetes Care. 2023. PMID: 36383478 Free PMC article.
-
Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy.PeerJ. 2022 Jun 23;10:e13632. doi: 10.7717/peerj.13632. eCollection 2022. PeerJ. 2022. PMID: 35765591 Free PMC article.
-
NPAHs and OPAHs in the atmosphere of two central European cities: Seasonality, urban-to-background gradients, cancer risks and gas-to-particle partitioning.Sci Total Environ. 2021 Nov 1;793:148528. doi: 10.1016/j.scitotenv.2021.148528. Epub 2021 Jun 25. Sci Total Environ. 2021. PMID: 34328964 Free PMC article.
-
Characterization and in vitro biological effects of ambient air PM10 from a rural, an industrial and an urban site in Sulaimani City, Iraq.Toxicol Environ Chem. 2018;100(4):373-394. doi: 10.1080/02772248.2018.1520234. Epub 2018 Oct 29. Toxicol Environ Chem. 2018. PMID: 31534295 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous