Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors
- PMID: 18953354
- DOI: 10.1038/nbt.1506
Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors
Abstract
Dietary consumption of anthocyanins, a class of pigments produced by higher plants, has been associated with protection against a broad range of human diseases. However, anthocyanin levels in the most commonly eaten fruits and vegetables may be inadequate to confer optimal benefits. When we expressed two transcription factors from snapdragon in tomato, the fruit of the plants accumulated anthocyanins at levels substantially higher than previously reported for efforts to engineer anthocyanin accumulation in tomato and at concentrations comparable to the anthocyanin levels found in blackberries and blueberries. Expression of the two transgenes enhanced the hydrophilic antioxidant capacity of tomato fruit threefold and resulted in fruit with intense purple coloration in both peel and flesh. In a pilot test, cancer-susceptible Trp53(-/-) mice fed a diet supplemented with the high-anthocyanin tomatoes showed a significant extension of life span.
Similar articles
-
Genetic and Biotechnological Approaches to Improve Fruit Bioactive Content: A Focus on Eggplant and Tomato Anthocyanins.Int J Mol Sci. 2024 Jun 20;25(12):6811. doi: 10.3390/ijms25126811. Int J Mol Sci. 2024. PMID: 38928516 Free PMC article. Review.
-
In pursuit of purple: anthocyanin biosynthesis in fruits of the tomato clade.Trends Plant Sci. 2024 May;29(5):589-604. doi: 10.1016/j.tplants.2023.12.010. Epub 2024 Jan 4. Trends Plant Sci. 2024. PMID: 38177013 Review.
-
Comparative transcriptome analysis of differentially expressed genes between the fruit peel and flesh of the purple tomato cultivar 'Indigo Rose'.Plant Signal Behav. 2020 Jun 2;15(6):1752534. doi: 10.1080/15592324.2020.1752534. Epub 2020 Apr 26. Plant Signal Behav. 2020. PMID: 32338177 Free PMC article.
-
A Transcriptional Network Promotes Anthocyanin Biosynthesis in Tomato Flesh.Mol Plant. 2020 Jan 6;13(1):42-58. doi: 10.1016/j.molp.2019.10.010. Epub 2019 Nov 1. Mol Plant. 2020. PMID: 31678614
-
Purple as a tomato: towards high anthocyanin tomatoes.Trends Plant Sci. 2009 May;14(5):237-41. doi: 10.1016/j.tplants.2009.02.001. Epub 2009 Apr 8. Trends Plant Sci. 2009. PMID: 19359211
Cited by
-
Biotechnological advances for improving natural pigment production: a state-of-the-art review.Bioresour Bioprocess. 2022 Jan 28;9(1):8. doi: 10.1186/s40643-022-00497-4. Bioresour Bioprocess. 2022. PMID: 38647847 Free PMC article. Review.
-
Identification and application of an exocarp-preferential promoter for genetic engineering of tomato fruit.Hortic Res. 2024 Jan 31;11(3):uhae035. doi: 10.1093/hr/uhae035. eCollection 2024 Mar. Hortic Res. 2024. PMID: 38544552 Free PMC article.
-
Harnessing genetic engineering to drive economic bioproduct production in algae.Front Bioeng Biotechnol. 2024 Jan 29;12:1350722. doi: 10.3389/fbioe.2024.1350722. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 38347913 Free PMC article. Review.
-
Glow way! Bioluminescent houseplant hits US market for first time.Nature. 2024 Feb;626(8000):701. doi: 10.1038/d41586-024-00383-3. Nature. 2024. PMID: 38337056 No abstract available.
-
Overexpression of R2R3-MYB IbMYB1a induces anthocyanin pigmentation in soybean cotyledon.Plant Cell Rep. 2024 Feb 6;43(2):56. doi: 10.1007/s00299-024-03142-w. Plant Cell Rep. 2024. PMID: 38319432
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials