Malignant peripheral nerve sheath tumors
- PMID: 19010279
- DOI: 10.1016/j.nec.2008.07.004
Malignant peripheral nerve sheath tumors
Abstract
Malignant peripheral nerve sheath tumors (MPNSTs) are a rare variety of soft tissue sarcoma of ectomesenchymal origin. MPNSTs arise from major or minor peripheral nerve branches or sheaths of peripheral nerve fibers and are derived from Schwann cells or pluripotent cells of neural crest origin. Arthur Purdy Stout played a pivotal role in the development of our current understanding of the pathogenesis of peripheral nerve sheath tumors by identifying the Schwann cell as the major contributor to the formation of benign and malignant neoplasms of the nerve sheath. Although this fact remains essentially true, the cell of origin of the MPNST remains elusive and has not yet conclusively been identified. Some have suggested these tumors may have multiple cell line origins. In the present review, MPNSTs and their epidemiology, diagnosis, management, and treatment are discussed.
Similar articles
-
Low-grade malignant triton tumor in the lumbar spine: a rare variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation.Neuropathology. 2012 Apr;32(2):180-9. doi: 10.1111/j.1440-1789.2011.01238.x. Epub 2011 Jul 7. Neuropathology. 2012. PMID: 21732991 Review.
-
Malignant peripheral nerve sheath tumor of the breast: case report.World J Surg Oncol. 2007 Dec 21;5:142. doi: 10.1186/1477-7819-5-142. World J Surg Oncol. 2007. PMID: 18154670 Free PMC article.
-
Malignant peripheral nerve sheath tumors.Neurosurg Focus. 2007 Jun 15;22(6):E12. doi: 10.3171/foc.2007.22.6.13. Neurosurg Focus. 2007. PMID: 17613203 Review.
-
[Buttock mass and malignant sciatic nerve tumor].Neurologia. 2004 Jan-Feb;19(1):27-31. Neurologia. 2004. PMID: 14762732 Spanish.
-
Malignant peripheral nerve sheath tumors developing multifocally in the central nervous system in a patient with neurofibromatosis type 2.Clin Neuropathol. 1998 Mar-Apr;17(2):115-20. Clin Neuropathol. 1998. PMID: 9561334
Cited by
-
Peripheral Nerve Sheath Tumor: A Diagnostic and Therapeutic Challenge.Cureus. 2024 Mar 20;16(3):e56601. doi: 10.7759/cureus.56601. eCollection 2024 Mar. Cureus. 2024. PMID: 38646284 Free PMC article.
-
Surgical management of craniospinal axis malignant peripheral nerve sheath tumors: a single-institution experience and literature review.World J Surg Oncol. 2023 Oct 26;21(1):338. doi: 10.1186/s12957-023-03227-y. World J Surg Oncol. 2023. PMID: 37880773 Free PMC article. Review.
-
Clinical diagnostic and radiographic features of recurrent intracranial malignant triton tumor in an adult: illustrative case.J Neurosurg Case Lessons. 2023 Aug 21;6(8):CASE23338. doi: 10.3171/CASE23338. Print 2023 Aug 21. J Neurosurg Case Lessons. 2023. PMID: 37728296 Free PMC article.
-
Malignant peripheral nerve sheath tumor mimicking an adnexal mass: a radio-pathologic correlation.Radiol Case Rep. 2022 Nov 2;18(1):250-255. doi: 10.1016/j.radcr.2022.09.104. eCollection 2023 Jan. Radiol Case Rep. 2022. PMID: 36353250 Free PMC article.
-
Diagnostic Performance of US and MRI in Predicting Malignancy of Soft Tissue Masses: Using a Scoring System.Front Oncol. 2022 Apr 29;12:853232. doi: 10.3389/fonc.2022.853232. eCollection 2022. Front Oncol. 2022. PMID: 35574339 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources