From promiscuity to precision: protein phosphatases get a makeover
- PMID: 19285938
- DOI: 10.1016/j.molcel.2009.02.015
From promiscuity to precision: protein phosphatases get a makeover
Abstract
The control of biological events requires strict regulation using complex protein phosphorylation and dephosphorylation strategies. The bulk of serine-threonine dephosphorylations are catalyzed by a handful of phosphatase catalytic subunits, giving rise to the misconception that these phosphatases are promiscuous and unregulated enzymes in vivo. The reality is much more nuanced: PP1 and PP2A, the most abundant serine-threonine phosphatases, are, in fact, families of hundreds of protein serine/threonine phosphatases, assembled from a few catalytic subunits in combination with a highly diverse array of regulators. As recent publications illustrate, these regulatory subunits confer specificity, selectivity, localization, and regulation on these important enzymes.
Similar articles
-
Serine/threonine phosphatases: mechanism through structure.Cell. 2009 Oct 30;139(3):468-84. doi: 10.1016/j.cell.2009.10.006. Cell. 2009. PMID: 19879837 Review.
-
Protein serine/threonine phosphatases: life, death, and sleeping.Curr Opin Cell Biol. 2005 Apr;17(2):197-202. doi: 10.1016/j.ceb.2005.01.002. Curr Opin Cell Biol. 2005. PMID: 15780597 Review.
-
Protein phosphatase 2A: variety of forms and diversity of functions.Acta Biochim Pol. 2001;48(4):921-33. Acta Biochim Pol. 2001. PMID: 11996003 Review.
-
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.Eur J Neurosci. 2005 Oct;22(8):1942-50. doi: 10.1111/j.1460-9568.2005.04391.x. Eur J Neurosci. 2005. PMID: 16262633
-
Protein phosphatases: structures and implications.Biochem Cell Biol. 1997;75(1):17-26. Biochem Cell Biol. 1997. PMID: 9192069 Review.
Cited by
-
Molecular Role of Protein Phosphatases in Alzheimer's and Other Neurodegenerative Diseases.Biomedicines. 2024 May 15;12(5):1097. doi: 10.3390/biomedicines12051097. Biomedicines. 2024. PMID: 38791058 Free PMC article. Review.
-
Differences between human male and female neutrophils in mRNA, translation efficiency, protein, and phosphoprotein profiles.Res Sq [Preprint]. 2024 Apr 23:rs.3.rs-4284171. doi: 10.21203/rs.3.rs-4284171/v1. Res Sq. 2024. PMID: 38746380 Free PMC article. Preprint.
-
Genomic landscape of glioblastoma without IDH somatic mutation in 42 cases: a comprehensive analysis using RNA sequencing data.J Neurooncol. 2024 May;167(3):489-499. doi: 10.1007/s11060-024-04628-z. Epub 2024 Apr 23. J Neurooncol. 2024. PMID: 38653957
-
The PP2A-like phosphatase Ppg1 mediates assembly of the Far complex to balance gluconeogenic outputs and enables adaptation to glucose depletion.PLoS Genet. 2024 Mar 7;20(3):e1011202. doi: 10.1371/journal.pgen.1011202. eCollection 2024 Mar. PLoS Genet. 2024. PMID: 38452140 Free PMC article.
-
Recruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B.Mol Cell. 2024 Feb 1;84(3):506-521.e11. doi: 10.1016/j.molcel.2023.12.011. Epub 2023 Dec 29. Mol Cell. 2024. PMID: 38159565 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
