Molecular mechanisms of mTOR-mediated translational control
- PMID: 19339977
- DOI: 10.1038/nrm2672
Molecular mechanisms of mTOR-mediated translational control
Abstract
The process of translation requires substantial cellular resources. Cells have therefore evolved complex mechanisms to control overall protein synthesis as well as the translation of specific mRNAs that are crucial for cell growth and proliferation. At the heart of this process is the mammalian target of rapamycin (mTOR) signalling pathway, which senses and responds to nutrient availability, energy sufficiency, stress, hormones and mitogens to modulate protein synthesis. Here, we highlight recent findings on the regulators and effectors of mTOR and discuss specific cases that serve as paradigms for the different modes of mTOR regulation and its control of translation.
Similar articles
-
Nutrient signalling in the regulation of human muscle protein synthesis.J Physiol. 2007 Jul 15;582(Pt 2):813-23. doi: 10.1113/jphysiol.2007.134593. Epub 2007 May 3. J Physiol. 2007. PMID: 17478528 Free PMC article.
-
The multifaceted role of mTOR in cellular stress responses.DNA Repair (Amst). 2004 Aug-Sep;3(8-9):927-34. doi: 10.1016/j.dnarep.2004.03.012. DNA Repair (Amst). 2004. PMID: 15279778 Review.
-
Role of mTOR signalling in the control of translation initiation and elongation by nutrients.Curr Top Microbiol Immunol. 2004;279:215-44. doi: 10.1007/978-3-642-18930-2_13. Curr Top Microbiol Immunol. 2004. PMID: 14560960 Review.
-
Coordinate regulation of translation by the PI 3-kinase and mTOR pathways.Adv Cancer Res. 2002;86:1-39. doi: 10.1016/s0065-230x(02)86001-8. Adv Cancer Res. 2002. PMID: 12374276 Review.
-
A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling.Biochem Pharmacol. 2002 Oct 1;64(7):1071-7. doi: 10.1016/s0006-2952(02)01263-7. Biochem Pharmacol. 2002. PMID: 12234610 Review.
Cited by
-
Low NDRG2, regulated by the MYC/MIZ-1 complex and methylation, predicts poor outcomes in DLBCL patients.Ann Hematol. 2024 Jun 6. doi: 10.1007/s00277-024-05829-2. Online ahead of print. Ann Hematol. 2024. PMID: 38842567
-
Role of PIM Kinase Inhibitor in the Treatment of Alzheimer's Disease.Mol Neurobiol. 2024 May 30. doi: 10.1007/s12035-024-04257-7. Online ahead of print. Mol Neurobiol. 2024. PMID: 38816674 Review.
-
Models of Herpes Simplex Virus Latency.Viruses. 2024 May 8;16(5):747. doi: 10.3390/v16050747. Viruses. 2024. PMID: 38793628 Free PMC article. Review.
-
The CTLH Ubiquitin Ligase Substrates ZMYND19 and MKLN1 Negatively Regulate mTORC1 at the Lysosomal Membrane.Res Sq [Preprint]. 2024 Apr 24:rs.3.rs-4259395. doi: 10.21203/rs.3.rs-4259395/v1. Res Sq. 2024. PMID: 38746323 Free PMC article. Preprint.
-
Upregulated Matrisomal Proteins and Extracellular Matrix Mechanosignaling Underlie Obesity-Associated Promotion of Pancreatic Ductal Adenocarcinoma.Cancers (Basel). 2024 Apr 21;16(8):1593. doi: 10.3390/cancers16081593. Cancers (Basel). 2024. PMID: 38672675 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous