Feasibility study of a retinal prosthesis: spatial vision with a 16-electrode implant
- PMID: 19365014
- DOI: 10.1001/archophthalmol.2009.20
Feasibility study of a retinal prosthesis: spatial vision with a 16-electrode implant
Abstract
Objective: To demonstrate that an epiretinal prosthesis can produce patterned visual perception in patients blinded by photoreceptor degeneration who have no other treatment options.
Methods: A totally blind subject with retinitis pigmentosa had a 16-electrode epiretinal prosthesis implanted. The implant is controlled wirelessly by an external computer or a head-mounted video camera. Spatial vision was assessed by measuring the subject's response to direct stimulation of patterns and by comparing the ability of the subject to identify the orientation of gratings with the system on and off.
Results: In response to stimulation of 2 orthogonal rows of electrodes, the subject drew 2 lines with a mean (SEM) angle of 87.4 degrees (1.8 degrees) between them. With the system on, the subject identified the orientation of the grating target up to a spatial resolution that matches the spacing between the adjacent electrodes. In contrast, with the system off, the subject could not detect or identify the target's orientation.
Conclusion: Synchronized stimulation of different retinal locations with an epiretinal prosthesis implanted long-term can produce spatial vision with an acuity level determined by the distance between the electrodes.
Trial registration: clinicaltrials.gov Identifier: NCT00279500.
Similar articles
-
The Argus(®) II Retinal Prosthesis System.Prog Retin Eye Res. 2016 Jan;50:89-107. doi: 10.1016/j.preteyeres.2015.09.003. Epub 2015 Sep 25. Prog Retin Eye Res. 2016. PMID: 26404104 Review.
-
The Detection of Motion by Blind Subjects With the Epiretinal 60-Electrode (Argus II) Retinal Prosthesis.JAMA Ophthalmol. 2013 Feb;131(2):183-9. doi: 10.1001/2013.jamaophthalmol.221. JAMA Ophthalmol. 2013. PMID: 23544203 Free PMC article. Clinical Trial.
-
The Argus™ II retinal prosthesis: factors affecting patient selection for implantation.Prog Retin Eye Res. 2013 Sep;36:1-23. doi: 10.1016/j.preteyeres.2013.01.002. Epub 2013 Mar 14. Prog Retin Eye Res. 2013. PMID: 23500412 Clinical Trial.
-
Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis.Prog Brain Res. 2009;175:317-32. doi: 10.1016/S0079-6123(09)17522-2. Prog Brain Res. 2009. PMID: 19660665 Review.
-
Factors affecting perceptual thresholds in epiretinal prostheses.Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2303-14. doi: 10.1167/iovs.07-0696. Invest Ophthalmol Vis Sci. 2008. PMID: 18515576 Free PMC article. Clinical Trial.
Cited by
-
Modeling of dielectric resonator antenna array for retina photoreceptors.Heliyon. 2023 Feb 21;9(3):e13794. doi: 10.1016/j.heliyon.2023.e13794. eCollection 2023 Mar. Heliyon. 2023. PMID: 36895386 Free PMC article.
-
Structural changes in the retina after implantation of subretinal three-dimensional implants in mini pigs.Front Neurosci. 2022 Sep 30;16:1010445. doi: 10.3389/fnins.2022.1010445. eCollection 2022. Front Neurosci. 2022. PMID: 36248640 Free PMC article.
-
Graphene coated dielectric resonator antenna for modeling the photoreceptors at visible spectrum.Heliyon. 2022 Jun 1;8(6):e09611. doi: 10.1016/j.heliyon.2022.e09611. eCollection 2022 Jun. Heliyon. 2022. PMID: 35928439 Free PMC article.
-
Brain-Machine Interfaces to Assist the Blind.Front Hum Neurosci. 2021 Feb 9;15:638887. doi: 10.3389/fnhum.2021.638887. eCollection 2021. Front Hum Neurosci. 2021. PMID: 33633557 Free PMC article. Review.
-
Oculomotor Responses to Dynamic Stimuli in a 44-Channel Suprachoroidal Retinal Prosthesis.Transl Vis Sci Technol. 2020 Dec 18;9(13):31. doi: 10.1167/tvst.9.13.31. eCollection 2020 Dec. Transl Vis Sci Technol. 2020. PMID: 33384885 Free PMC article.
Publication types
MeSH terms
Associated data
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources