Review
doi: 10.1093/glycob/cwp066.
Epub 2009 May 9.
Protein O-mannosylation: conserved from bacteria to humans
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- PMID: 19429925
- DOI: 10.1093/glycob/cwp066
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Review
Protein O-mannosylation: conserved from bacteria to humans
Glycobiology.
2009 Aug.
Abstract
Protein O-mannosylation is an essential modification in fungi and animals. Different from most other types of O-glycosylation, protein O-mannosylation is initiated in the endoplasmic reticulum by the transfer of mannose from dolichol monophosphate-activated mannose to serine and threonine residues of secretory proteins. In recent years, it has emerged that even bacteria are capable of O-mannosylation and that the biosynthetic pathway of O-mannosyl glycans is conserved between pro- and eukaryotes. In this review, we summarize the observations that have opened up the field and highlight characteristics of O-mannosylation in the different domains/kingdoms of life.
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