Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease
- PMID: 19494434
- DOI: 10.3233/JAD-2009-1015
Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease
Abstract
The distribution of peripheral T cell subsets in young and healthy old people is markedly different, characterized by decreased numbers of naïve cells and increased numbers and clonal expansions of memory cells, predominantly in the CD8+ MHC class I-restricted subset. Here, however, we document dramatic alterations in naïve and memory subsets of CD4+ cells in patients with mild Alzheimer's disease (AD), with greatly decreased percentages of naïve cells, elevated memory cells, and increased proportions of CD4+ but not CD8+ cells lacking the important costimulatory receptor CD28. CD4+CD25(high) potentially T regulatory cells with a naïve phenotype are also reduced in AD patients. Together these data provide stronger evidence than hitherto presented for more highly differentiated CD4+ as well as CD8+ T cells in AD patients, consistent with an adaptive immune system undergoing persistent antigenic challenge and possibly manifesting dysregulation as a result.
Similar articles
-
Reference values for CD4+ and CD8+ T lymphocytes with naïve or memory phenotype and their association with mortality in the elderly.Gerontology. 2009;55(3):314-21. doi: 10.1159/000199451. Epub 2009 Feb 4. Gerontology. 2009. PMID: 19190395
-
Postthymic development of CD28-CD8+ T cell subset: age-associated expansion and shift from memory to naive phenotype.J Immunol. 1999 Mar 15;162(6):3327-35. J Immunol. 1999. PMID: 10092786
-
Comparative analysis of naïve and memory CD4+ and CD8+ T-cell subsets in bone marrow and G-CSF-mobilized peripheral blood stem cell allografts: impact of donor characteristics.Exp Hematol. 2007 Jun;35(6):861-71. doi: 10.1016/j.exphem.2007.03.006. Exp Hematol. 2007. PMID: 17533040 Clinical Trial.
-
The immune system in extreme longevity.Exp Gerontol. 2008 Feb;43(2):61-5. doi: 10.1016/j.exger.2007.06.008. Epub 2007 Jul 4. Exp Gerontol. 2008. PMID: 17870272 Review.
-
Crossing borders in Alzheimer's disease: A T cell's perspective.Adv Drug Deliv Rev. 2022 Sep;188:114398. doi: 10.1016/j.addr.2022.114398. Epub 2022 Jun 30. Adv Drug Deliv Rev. 2022. PMID: 35780907 Review.
Cited by
-
Consideration of T-Cell Profile in the Examination of Statin Efficacy in Inflammatory Diseases, Neurodegeneration, and Neurocognitive Performance.J Gerontol A Biol Sci Med Sci. 2024 Aug 1;79(8):glae156. doi: 10.1093/gerona/glae156. J Gerontol A Biol Sci Med Sci. 2024. PMID: 38963798 Free PMC article. Review.
-
CD4+ T-Cell Senescence in Neurodegenerative Disease: Pathogenesis and Potential Therapeutic Targets.Cells. 2024 Apr 25;13(9):749. doi: 10.3390/cells13090749. Cells. 2024. PMID: 38727285 Free PMC article. Review.
-
The immunomodulatory effects of mesenchymal stem cell-derived extracellular vesicles in Alzheimer's disease.Front Immunol. 2024 Jan 8;14:1325530. doi: 10.3389/fimmu.2023.1325530. eCollection 2023. Front Immunol. 2024. PMID: 38259476 Free PMC article. Review.
-
Therapeutic Effects of Aβ-Specific Regulatory T Cells in Alzheimer's Disease: A Study in 5xFAD Mice.Int J Mol Sci. 2024 Jan 8;25(2):783. doi: 10.3390/ijms25020783. Int J Mol Sci. 2024. PMID: 38255856 Free PMC article.
-
Distinguishing features of depression in dementia from primary psychiatric disease.Discov Ment Health. 2024 Jan 4;4(1):3. doi: 10.1007/s44192-023-00057-y. Discov Ment Health. 2024. PMID: 38175420 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials