New aspects of rapid aldosterone signaling
- PMID: 19549592
- DOI: 10.1016/j.mce.2009.02.005
New aspects of rapid aldosterone signaling
Abstract
Aldosterone, the endogenous ligand of the mineralocorticoid receptor (MR) in humans, is a steroid hormone that regulates salt and water homeostasis. Recently, additional pathophysiological effects in the renocardiovascular system have been identified. Besides genomic effects mediated by activated MR, rapid aldosterone actions that are independent of translation and transcription have been documented. While these nongenomic actions influence electrolyte homeostasis, pH and cell volume in classical MR target organs, they also participate in pathophysiological effects in the renocardiovascular system causing endothelial dysfunction, inflammation and remodeling. The mechanisms conveying these rapid effects consist of a multitude of signaling molecules and include a cross-talk with genomic aldosterone effects as well as with angiotensin II and epidermal growth factor receptor signaling. Rapid corticosteroid signaling via the MR has also been demonstrated in the brain. Altogether, the function of nongenomic aldosterone effects seems to be to modulate other signaling cascades, depending on the surrounding milieu.
Similar articles
-
Interaction between mineralocorticoid receptor and epidermal growth factor receptor signaling.Mol Cell Endocrinol. 2012 Mar 24;350(2):235-41. doi: 10.1016/j.mce.2011.07.045. Epub 2011 Jul 29. Mol Cell Endocrinol. 2012. PMID: 21827828 Review.
-
Interaction between mineralocorticoid receptor and cAMP/CREB signaling.Steroids. 2010 Aug-Sep;75(8-9):539-43. doi: 10.1016/j.steroids.2009.10.006. Epub 2009 Oct 30. Steroids. 2010. PMID: 19879890 Review.
-
Nongenotropic aldosterone effects and the EGFR: interaction and biological relevance.Steroids. 2008 Oct;73(9-10):973-8. doi: 10.1016/j.steroids.2007.12.008. Epub 2007 Dec 23. Steroids. 2008. PMID: 18249428 Review.
-
Nongenomic actions of aldosterone: physiological or pathophysiological role?Steroids. 2006 Apr;71(4):277-80. doi: 10.1016/j.steroids.2005.09.017. Epub 2005 Nov 8. Steroids. 2006. PMID: 16280143 Review.
-
Early nongenomic events in aldosterone action in renal collecting duct cells: PKCalpha activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response.J Am Soc Nephrol. 2004 May;15(5):1145-60. J Am Soc Nephrol. 2004. PMID: 15100355
Cited by
-
G protein-coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension.Front Endocrinol (Lausanne). 2023 Aug 17;14:1226458. doi: 10.3389/fendo.2023.1226458. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37664844 Free PMC article. Review.
-
Aldosterone Synthase Inhibitors and Dietary Interventions: A Combined Novel Approach for Prevention and Treatment of Cardiovascular Disease.Cureus. 2023 Mar 15;15(3):e36184. doi: 10.7759/cureus.36184. eCollection 2023 Mar. Cureus. 2023. PMID: 36937127 Free PMC article. Review.
-
Cortisol Interaction with Aquaporin-2 Modulates Its Water Permeability: Perspectives for Non-Genomic Effects of Corticosteroids.Int J Mol Sci. 2023 Jan 12;24(2):1499. doi: 10.3390/ijms24021499. Int J Mol Sci. 2023. PMID: 36675012 Free PMC article.
-
Cardiac Mineralocorticoid Receptor and the Na+/H+ Exchanger: Spilling the Beans.Front Cardiovasc Med. 2021 Jan 20;7:614279. doi: 10.3389/fcvm.2020.614279. eCollection 2020. Front Cardiovasc Med. 2021. PMID: 33553262 Free PMC article. Review.
-
Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats.Nutr Metab (Lond). 2020 Aug 12;17:66. doi: 10.1186/s12986-020-00488-2. eCollection 2020. Nutr Metab (Lond). 2020. PMID: 32817751 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
