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Review
. 2009 Sep;16(9):1131-5.
doi: 10.1016/j.jocn.2009.03.005. Epub 2009 Jun 24.

Frontotemporal dementia and motor neurone disease: overlapping clinic-pathological disorders

Patricia Lillo  1 , John R Hodges
Affiliations
Review

Frontotemporal dementia and motor neurone disease: overlapping clinic-pathological disorders

Patricia Lillo et al. J Clin Neurosci. 2009 Sep.

Abstract

Advances in genetics and pathology have supported the idea of a continuum between frontotemporal dementia (FTD) and motor neurone disease (MND), which is strengthened by the discovery of the trans-activating responsive (Tar) sequence DNA binding protein (TDP-43) as a key component in the underlying pathology of FTD, FTD-MND and sporadic and familial MND patients. MND is a multisystem disorder associated with cognitive and behavioural changes which in some instances reaches the criteria for FTD, while a proportion of patients with FTD develop frank MND. We review the overlap between FTD and MND, emphasizing areas of controversy and uncertainty.

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