Coats-like retinitis pigmentosa: Reports of three cases
- PMID: 19668510
- PMCID: PMC2704518
Coats-like retinitis pigmentosa: Reports of three cases
Abstract
Purpose: Describing the ophthalmic findings of an exudative vasculopathy called as Coats-like retinitis pigmentosa on three patients. The etiology of the Coats-like retinitis pigmentosa is obscure. The principal theories have been discussed in this article.
Methods: Three observational case series have been discussed. Complete ophthalmic examinations and color fundus photos, visual field, and fluorescein angiography have been performed.
Results: We have identified 3 patients who have some typical clinical features of Coats-like retinitis pigmentosa; peripheral serous retinal detachment, telangiectasia, prominent lipid deposition, pigmentary changes in peripheral retina, and loss of vision. None of the three patients had positive family history. All of the patients have had symptoms of nyctalopia, decreased central vision, and two of them have had constriction of visual field. All of the patients have had cataracts and two of them underwent cataract surgery. Fundus examination and fluorescein angiography of patients revealed typical retinitis pigmentosa with Coats-type changes in bilateral inferiotemporal quadrants.
Conclusion: A better understanding of clinical features and genetic etiology of Coats-type retinitis pigmentosa will aid diagnosis and development of new therapies. If sufficient conditions arise, genetic factors that influence the expression of CRB1 mutations in Coats-like retinitis pigmentosa should be detected.
Keywords: Coats-like retinitis pigmentosa; exudative retinal detachment.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2704518/bin/opth-1-193f1.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2704518/bin/opth-1-193f2.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2704518/bin/opth-1-193f3.gif)
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2704518/bin/opth-1-193f4.gif)
![Figure 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2704518/bin/opth-1-193f5.gif)
Similar articles
-
Clinical spectrum, genetic associations and management outcomes of Coats-like exudative retinal vasculopathy in autosomal recessive retinitis pigmentosa.Ophthalmic Genet. 2021 Apr;42(2):178-185. doi: 10.1080/13816810.2020.1867754. Epub 2021 Jan 13. Ophthalmic Genet. 2021. PMID: 33441055
-
Coats-like Exudative Vitreoretinopathy in Retinitis Pigmentosa: Ocular Manifestations and Treatment Outcomes.Ophthalmol Retina. 2021 Jan;5(1):86-96. doi: 10.1016/j.oret.2020.03.026. Epub 2020 Apr 9. Ophthalmol Retina. 2021. PMID: 32507488 Free PMC article.
-
A case of CRB1-negative Coats-like retinitis pigmentosa.J AAPOS. 2013 Aug;17(4):414-6. doi: 10.1016/j.jaapos.2013.02.010. Epub 2013 Jul 18. J AAPOS. 2013. PMID: 23871396
-
Coats'-type retinitis pigmentosa.Surv Ophthalmol. 1988 Mar-Apr;32(5):317-32. doi: 10.1016/0039-6257(88)90094-x. Surv Ophthalmol. 1988. PMID: 2457260 Review.
-
[Pigmentary retinopathy and Coats' vasculopathy].Oftalmologia. 1990 Apr-Jun;34(2):135-42. Oftalmologia. 1990. PMID: 2101044 Review. Romanian.
Cited by
-
Application of intravitreal aflibercept to treat bilateral exudative retinal detachment secondary to retinitis pigmentosa: Case report and review of literature.Medicine (Baltimore). 2023 Dec 22;102(51):e36589. doi: 10.1097/MD.0000000000036589. Medicine (Baltimore). 2023. PMID: 38134121 Free PMC article. Review.
-
Coats-like Vasculopathy in Inherited Retinal Disease: Prevalence, Characteristics, Genetics, and Management.Ophthalmology. 2023 Dec;130(12):1327-1335. doi: 10.1016/j.ophtha.2023.07.027. Epub 2023 Aug 5. Ophthalmology. 2023. PMID: 37544434 Free PMC article.
-
Paradoxical Exudative Retinopathy and Macular Star Formation After Treatment Initiation in Coats Disease.J Vitreoretin Dis. 2022 Aug 8;6(6):452-456. doi: 10.1177/24741264221075962. eCollection 2022 Nov-Dec. J Vitreoretin Dis. 2022. PMID: 37009530 Free PMC article.
-
Multimodal treatment of Coats-like exudative vitreoretinopathy in Goldmann-Favre syndrome.Am J Ophthalmol Case Rep. 2022 Jan 29;25:101362. doi: 10.1016/j.ajoc.2022.101362. eCollection 2022 Mar. Am J Ophthalmol Case Rep. 2022. PMID: 35243140 Free PMC article.
-
Idiopathic Peripheral Retinal Telangiectasia in Adults: A Case Series and Literature Review.J Clin Med. 2021 Apr 19;10(8):1767. doi: 10.3390/jcm10081767. J Clin Med. 2021. PMID: 33921646 Free PMC article.
References
-
- Berson EL, Rosner B, Sandberg MA, et al. Vitamin A supplementation for retinitis pigmentosa. Arch Ophthalmol. 1993;111:1456–66. - PubMed
-
- Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet. 2006;368:1795–809. - PubMed
-
- Kajiwara Y. Ocular complications of retinitis pigmentosa. Association with Coat’s syndrome. Jpn J Clin Ophthalmol. 1980;34:947–55.
Publication types
LinkOut - more resources
Full Text Sources