The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet
- PMID: 19747233
- PMCID: PMC2783987
- DOI: 10.1111/j.1474-9726.2009.00520.x
The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet
Abstract
The interaction of longevity-conferring genes with longevity-conferring diets is poorly understood. The growth hormone receptor gene-disrupted (GHR-KO) mouse is long lived; and this longevity is not responsive to 30% caloric restriction, in contrast to wild-type animals from the same strain. To determine whether this may have been limited to a particular level of dietary restriction, we subjected GHR-KO mice to a different dietary restriction regimen, an intermittent fasting diet. The intermittent fasting diet increased the survivorship and improved insulin sensitivity of normal males, but failed to affect either parameter in GHR-KO mice. From the results of two paradigms of dietary restriction, we postulate that GHR-KO mice would be resistant to any manner of dietary restriction; potentially due to their inability to further enhance insulin sensitivity. Insulin sensitivity may be a mechanism and/or a marker of the lifespan extending potential of an intervention.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2783987/bin/nihms146189f1a.gif)
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2783987/bin/nihms146189f1a.gif)
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2783987/bin/nihms146189f1a.gif)
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2783987/bin/nihms146189f1a.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2783987/bin/nihms146189f2a.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2783987/bin/nihms146189f2a.gif)
Similar articles
-
Deconstructing the Growth Hormone Receptor(GHR): Physical and Metabolic Phenotypes of Tissue-Specific GHR Gene-Disrupted Mice.Prog Mol Biol Transl Sci. 2016;138:27-39. doi: 10.1016/bs.pmbts.2015.10.014. Epub 2016 Jan 13. Prog Mol Biol Transl Sci. 2016. PMID: 26940385 Review.
-
Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice.Exp Gerontol. 2005 Aug-Sep;40(8-9):679-84. doi: 10.1016/j.exger.2005.06.003. Exp Gerontol. 2005. PMID: 16054319
-
Life extension in the dwarf mouse.Curr Top Dev Biol. 2004;63:189-225. doi: 10.1016/S0070-2153(04)63006-7. Curr Top Dev Biol. 2004. PMID: 15536017 Review.
-
Antioxidant enzymes, free-radical damage, and response to paraquat in liver and kidney of long-living growth hormone receptor/binding protein gene-disrupted mice.Horm Metab Res. 2002 Sep;34(9):481-6. doi: 10.1055/s-2002-34787. Horm Metab Res. 2002. PMID: 12384824
-
Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse.Exp Biol Med (Maywood). 2001 Jun;226(6):552-8. doi: 10.1177/153537020122600607. Exp Biol Med (Maywood). 2001. PMID: 11395925
Cited by
-
Intermittent and periodic fasting, longevity and disease.Nat Aging. 2021 Jan;1(1):47-59. doi: 10.1038/s43587-020-00013-3. Epub 2021 Jan 14. Nat Aging. 2021. PMID: 35310455 Free PMC article.
-
The Mechanism of Stem Cell Aging.Stem Cell Rev Rep. 2022 Apr;18(4):1281-1293. doi: 10.1007/s12015-021-10317-5. Epub 2022 Jan 9. Stem Cell Rev Rep. 2022. PMID: 35000109 Free PMC article. Review.
-
Why stem/progenitor cells lose their regenerative potential.World J Stem Cells. 2021 Nov 26;13(11):1714-1732. doi: 10.4252/wjsc.v13.i11.1714. World J Stem Cells. 2021. PMID: 34909119 Free PMC article. Review.
-
Importance of circadian timing for aging and longevity.Nat Commun. 2021 May 17;12(1):2862. doi: 10.1038/s41467-021-22922-6. Nat Commun. 2021. PMID: 34001884 Free PMC article. Review.
-
Healthful aging mediated by inhibition of oxidative stress.Ageing Res Rev. 2020 Dec;64:101194. doi: 10.1016/j.arr.2020.101194. Epub 2020 Oct 19. Ageing Res Rev. 2020. PMID: 33091597 Free PMC article. Review.
References
-
- Anson RM, Guo Z, de Cabo R, Iyun T, Rios M, Hagepanos A, Ingram DK, Lane MA, Mattson MP. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6216–6220. - PMC - PubMed
-
- Arum O, Johnson TE. Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1-results in increased longevity. J Gerontol A Biol Sci Med Sci. 2007;62(9):951–959. - PubMed
-
- Barrows CH, Jr, Kokkonen G. The effect of various dietary restricted regimes on biochemical variables in the mouse. Growth. 1978;42(1):71–85. - PubMed
-
- Bartke A, Wright JC, Mattison JA, Ingram DK, Miller RA, Roth GS. Extending the lifespan of long-lived mice. Nature. 2001 Nov 22;414(6862):412. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials