Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Nov 1;47(9):1267-75.
doi: 10.1016/j.freeradbiomed.2009.09.005. Epub 2009 Sep 11.

Redox regulation of adaptive responses in skeletal muscle to contractile activity

Malcolm J Jackson  1
Affiliations
Review

Redox regulation of adaptive responses in skeletal muscle to contractile activity

Malcolm J Jackson. Free Radic Biol Med. .

Abstract

Skeletal muscle is a highly malleable tissue that responds to changes in its pattern of activity or the mechanical and environmental stresses placed upon it. The signaling pathways involved in these multiple adaptations are increasingly well described, but there is a lack of information on the factors responsible for initiating these processes. Reactive oxygen species (ROS) are produced at various sites in skeletal muscle and there is increasing evidence that these species play targeted roles in modulating redox-sensitive signaling pathways that are important to the muscle for making adaptations. This review will outline some of the processes involved and the types of experimental approaches that seem necessary to fully evaluate these redox signaling systems in muscle. To understand how labile, highly reactive ROS can play a role in cell signaling that is discrete and yet regulated to prevent oxidative damage, an increased knowledge of the subcellular localization and compartmentalization of both ROS generation and the redox-sensitive targets of ROS activity is required. It seems likely that application of this increased knowledge will lead to new approaches to manipulating muscle metabolism to maintain health and prevent loss of muscle function in age-related diseases.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

Substances

LinkOut - more resources

-