Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?

doi:10.3390/ijms10093951

Review

. 2009 Sep 9;10(9):3951-3970.

doi: 10.3390/ijms10093951.

Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?

Lars Steinstraesser¹, Ursula M Kraneburg¹, Tobias Hirsch¹, Marco Kesting², Hans-Ulrich Steinau¹, Frank Jacobsen¹, Sammy Al-Benna¹

Affiliations

¹ Department of Plastic and Reconstructive Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Nordrhein-Westfalen, Germany.
² Department of Oral and Maxillofacial Surgery, Technische Universität München, Ismaninger Str. 22, München, Germany.

PMID: 19865528
PMCID: PMC2769137
DOI: 10.3390/ijms10093951

Review

Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?

Lars Steinstraesser et al. Int J Mol Sci. 2009.

. 2009 Sep 9;10(9):3951-3970.

doi: 10.3390/ijms10093951.

Authors

Lars Steinstraesser¹, Ursula M Kraneburg¹, Tobias Hirsch¹, Marco Kesting², Hans-Ulrich Steinau¹, Frank Jacobsen¹, Sammy Al-Benna¹

Affiliations

¹ Department of Plastic and Reconstructive Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Nordrhein-Westfalen, Germany.
² Department of Oral and Maxillofacial Surgery, Technische Universität München, Ismaninger Str. 22, München, Germany.

PMID: 19865528
PMCID: PMC2769137
DOI: 10.3390/ijms10093951

Abstract

Host defense peptides can modulate the innate immune response and boost infection-resolving immunity, while dampening potentially harmful pro-inflammatory (septic) responses. Both antimicrobial and/or immunomodulatory activities are an integral part of the process of innate immunity, which itself has many of the hallmarks of successful anti-infective therapies, namely rapid action and broad-spectrum antimicrobial activities. This gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections. This review details the role and activities of these peptides, and examines their applicability as development candidates for use against bacterial infections.

Keywords: antimicrobial peptides; bacterial infection; host defense peptides; inflammation; innate immunity; sepsis.

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References

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[1] Davies J. Origins and evolution of antibiotic resistance. Microbiologia. 1996;12:9–16. - PubMed

[2] Davies J. Origins and evolution of antibiotic resistance. Microbiologia. 1996;12:9–16. - PubMed

[3] Barber M, Rozwadowska-Dowzenko M. Infection by penicillin-resistant staphylococci. Lancet. 1948;2:641–644. - PubMed

[4] Barber M, Rozwadowska-Dowzenko M. Infection by penicillin-resistant staphylococci. Lancet. 1948;2:641–644. - PubMed

[5] Benner EJ, Kayser FH. Growing clinical significance of methcillin-resistant Staphylococcus aureus. Lancet. 1968;2:741–744. - PubMed

[6] Benner EJ, Kayser FH. Growing clinical significance of methcillin-resistant Staphylococcus aureus. Lancet. 1968;2:741–744. - PubMed

[7] Armstrong GL, Conn LA, Pinner RW. Trends in infectious disease mortality in the United States during the 20th century. JAMA. 1999;281:61–66. - PubMed

[8] Armstrong GL, Conn LA, Pinner RW. Trends in infectious disease mortality in the United States during the 20th century. JAMA. 1999;281:61–66. - PubMed

[9] Surveillance for methicillin-resistant Staphylococcus aureus in Canadian hospitals--a report update from the Canadian Nosocomial Infection Surveillance Program. Can. Commun. Dis. Rep. 2005;31:33–40. - PubMed

[10] Surveillance for methicillin-resistant Staphylococcus aureus in Canadian hospitals--a report update from the Canadian Nosocomial Infection Surveillance Program. Can. Commun. Dis. Rep. 2005;31:33–40. - PubMed

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Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?

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Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?

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