Selenium and selenoproteins in health and disease
- PMID: 19905883
- DOI: 10.1089/ars.2009.2973
Selenium and selenoproteins in health and disease
Abstract
The beneficial role of the trace element selenium (Se) in human health has been known for several decades and is attributed both to low-molecular-weight Se compounds and to its presence within 25 selenoproteins in the form of the amino acid selenocysteine (Sec). Incorporation of Sec into selenoproteins involves decoding of the UGA codon. This process requires multiple features, such as the Sec-insertion sequence (SECIS) element and protein factors, including a specific elongation factor EFSec and the SECIS-binding protein 2, SBP2. Although many selenoproteins remain functionally uncharacterized, some of their known functions include redox regulation of intracellular signaling, redox homeostasis, and thyroid hormone metabolism. Pathologically, reduced expression of selenoproteins has been directly linked with the congenital muscle disease referred to as selenoprotein N (SEPN)-related myopathy and with thyroid-hormone metabolism defects (deficiency of deiodinases due to genetic defects in SBP2). From a broader, less well defined aspect, selenium compounds and selenoproteins have been linked to prevention of some forms of cancer, Alzheimer's disease, cardiovascular disease, and life span. This forum summarizes recent advances in our understanding of important roles of selenium, selenoproteins, and factors involved in selenoprotein synthesis in health and disease and discusses potential targets for therapy.
Similar articles
-
Site-Specific Selenocysteine Incorporation into Proteins by Genetic Engineering.Chembiochem. 2021 Oct 13;22(20):2918-2924. doi: 10.1002/cbic.202100124. Epub 2021 Jun 25. Chembiochem. 2021. PMID: 33949764 Review.
-
Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2.RNA Biol. 2014;11(11):1402-13. doi: 10.1080/15476286.2014.996472. RNA Biol. 2014. PMID: 25692238 Free PMC article.
-
Selective up-regulation of human selenoproteins in response to oxidative stress.J Biol Chem. 2014 May 23;289(21):14750-61. doi: 10.1074/jbc.M114.551994. Epub 2014 Apr 4. J Biol Chem. 2014. PMID: 24706762 Free PMC article.
-
SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress.Antioxid Redox Signal. 2010 Apr 1;12(7):797-808. doi: 10.1089/ars.2009.2913. Antioxid Redox Signal. 2010. PMID: 19803747
-
From selenium to selenoproteins: synthesis, identity, and their role in human health.Antioxid Redox Signal. 2007 Jul;9(7):775-806. doi: 10.1089/ars.2007.1528. Antioxid Redox Signal. 2007. PMID: 17508906 Review.
Cited by
-
Effects of selenium and iodine on Kashin-Beck disease: an updated review.Front Nutr. 2024 May 2;11:1402559. doi: 10.3389/fnut.2024.1402559. eCollection 2024. Front Nutr. 2024. PMID: 38757132 Free PMC article. Review.
-
Reactions of hypobromous acid with dimethyl selenide, dimethyl diselenide and other organic selenium compounds: kinetics and product formation.Environ Sci (Camb). 2024 Jan 8;10(3):620-630. doi: 10.1039/d3ew00787a. eCollection 2024 Mar 1. Environ Sci (Camb). 2024. PMID: 38434173 Free PMC article.
-
The progression of inorganic nanoparticles and natural products for inflammatory bowel disease.J Nanobiotechnology. 2024 Jan 3;22(1):17. doi: 10.1186/s12951-023-02246-x. J Nanobiotechnology. 2024. PMID: 38172992 Free PMC article. Review.
-
Effects of Gestational Diabetes Mellitus and Selenium Deficiency on the Offspring Growth and Blood Glucose Mechanisms of C57BL/6J Mice.Nutrients. 2023 Oct 25;15(21):4519. doi: 10.3390/nu15214519. Nutrients. 2023. PMID: 37960172 Free PMC article.
-
Selenium-binding protein 1 inhibits malignant progression and induces apoptosis via distinct mechanisms in non-small cell lung cancer.Cancer Med. 2023 Aug;12(16):17149-17170. doi: 10.1002/cam4.6309. Epub 2023 Aug 22. Cancer Med. 2023. PMID: 37606338 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources