Assessing the arsenic-contaminated rice (Oryza sativa) associated children skin lesions
- PMID: 19945215
- DOI: 10.1016/j.jhazmat.2009.11.019
Assessing the arsenic-contaminated rice (Oryza sativa) associated children skin lesions
Abstract
The purpose of this study was to assess the potential risk of children skin lesions from arsenic-contaminated rice (Oryza sativa) consumption in West Bengal (India). Published age- and gender-specific skin lesions data in West Bengal were reanalyzed and incorporated into a Weibull dose-response model to predict children skin lesion prevalence. Monomethylarsonous acid (MMA(III)) levels in urine was used as a biomarker that could be predicted from a human physiologically based pharmacokinetic (PBPK) model. This study integrated arsenic contents in irrigation water, bioaccumulation factors of paddy soil, cooking methods, and arsenic bioavailability of cooked rice in gastrointestinal tract into a probabilistic risk model. Results indicated that children aged between 13 and 18 years might pose a relative higher potential risk of skin lesions to arsenic-contaminated cooked rice (odds ratios (ORs)=1.18 (95% CI 1.12-2.15)) than those of 1-6 years children (ORs=0.98 (0.85-1.40)). This study revealed the need to consider the relationships between cooking method and arsenic in cooked rice when assessing the risk associated with children skin lesions from rice consumption. This study suggested that arsenic-associated skin lesions risk from arsenic-contaminated rice consumption would be reduced significantly by adopting traditional rice cooking method (wash until clean; rice:water=1:6; discard excess water) as followed in West Bengal (India) and using water containing lower arsenic (e.g., <10 microg L(-1)) for cooking.
2009 Elsevier B.V. All rights reserved.
Similar articles
-
A Weibull-PBPK model for assessing risk of arsenic-induced skin lesions in children.Sci Total Environ. 2008 Mar 25;392(2-3):203-17. doi: 10.1016/j.scitotenv.2007.12.017. Epub 2008 Jan 22. Sci Total Environ. 2008. PMID: 18207220
-
Arsenic burden of cooked rice: Traditional and modern methods.Food Chem Toxicol. 2006 Nov;44(11):1823-9. doi: 10.1016/j.fct.2006.06.003. Epub 2006 Jun 28. Food Chem Toxicol. 2006. PMID: 16876928
-
Effect of cooking method and rice type on arsenic concentration in cooked rice and the estimation of arsenic dietary intake in a rural village in West Bengal, India.Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Nov;25(11):1345-52. doi: 10.1080/02652030802189732. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008. PMID: 19680842
-
High levels of inorganic arsenic in rice in areas where arsenic-contaminated water is used for irrigation and cooking.Sci Total Environ. 2011 Oct 15;409(22):4645-55. doi: 10.1016/j.scitotenv.2011.07.068. Epub 2011 Sep 6. Sci Total Environ. 2011. PMID: 21899878 Review.
-
Effect of drinking arsenic contaminated water in children.Indian Pediatr. 2007 Dec;44(12):925-7. Indian Pediatr. 2007. PMID: 18175848 Review.
Cited by
-
Update of the risk assessment of inorganic arsenic in food.EFSA J. 2024 Jan 18;22(1):e8488. doi: 10.2903/j.efsa.2024.8488. eCollection 2024 Jan. EFSA J. 2024. PMID: 38239496 Free PMC article.
-
Arsenic toxicokinetic modeling and risk analysis: Progress, needs and applications.Toxicology. 2021 Jun 15;457:152809. doi: 10.1016/j.tox.2021.152809. Epub 2021 May 7. Toxicology. 2021. PMID: 33965444 Free PMC article. Review.
-
Applying a Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Modeling.Front Pharmacol. 2018 Jun 8;9:588. doi: 10.3389/fphar.2018.00588. eCollection 2018. Front Pharmacol. 2018. PMID: 29937730 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical