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. 1991 Apr;11(4):2253-62.
doi: 10.1128/mcb.11.4.2253-2262.1991.

The SIR1 gene of Saccharomyces cerevisiae and its role as an extragenic suppressor of several mating-defective mutants

E M Stone  1 , M J Swanson, A M Romeo, J B Hicks, R Sternglanz
Affiliations

The SIR1 gene of Saccharomyces cerevisiae and its role as an extragenic suppressor of several mating-defective mutants

E M Stone et al. Mol Cell Biol. 1991 Apr.

Abstract

The SIR1 gene product of Saccharomyces cerevisiae is one of several proteins involved in repressing transcription of the silent mating-type genes. Strains with mutations in the genes coding for these proteins are defective in mating due to derepression of the silent loci. We have found that overexpression of the SIR1 gene suppresses the mating defects of several of these mutants, including nat1 and ard1 mutants (the products of these two genes are responsible for N-terminal acetylation of a subset of yeast proteins), certain sir3 mutants, and a histone H4 mutant. The SIR1 gene has been sequenced and found to contain an open reading frame coding for a 678-amino-acid protein.

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References

    1. Genetics. 1979 Dec;93(4):877-901 - PubMed
    1. EMBO J. 1987 Feb;6(2):461-7 - PubMed
    1. Cell. 1982 Nov;31(1):183-92 - PubMed
    1. Cell. 1983 Jun;33(2):519-27 - PubMed
    1. J Mol Biol. 1984 Jul 5;176(3):307-31 - PubMed

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