Comment
doi: 10.1038/jid.2009.331.
Could aging human skin use a connective tissue growth factor boost to increase collagen content?
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- PMID: 20081886
- DOI: 10.1038/jid.2009.331
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Comment
Could aging human skin use a connective tissue growth factor boost to increase collagen content?
J Invest Dermatol.
2010 Feb.
Free article
Abstract
The roles of connective tissue growth factor (CTGF) and transforming growth factor-beta (TGF-beta), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-beta, and type I procollagen expression and content. CTGF knockdown and TGF-beta blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-beta/Smad signaling-dependent mechanism without involving Smad2/3.
Comment on
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Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin.J Invest Dermatol. 2010 Feb;130(2):415-24. doi: 10.1038/jid.2009.224. Epub 2009 Jul 30. J Invest Dermatol. 2010. PMID: 19641518 Free PMC article.
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