Case Reports
doi: 10.1002/pbc.22401.
Sirolimus therapy for fibromatosis and multifocal renal cell carcinoma in a child with tuberous sclerosis complex
Affiliations
- PMID: 20108343
- DOI: 10.1002/pbc.22401
Item in Clipboard
Case Reports
Sirolimus therapy for fibromatosis and multifocal renal cell carcinoma in a child with tuberous sclerosis complex
Pediatr Blood Cancer.
.
Abstract
A male with tuberous sclerosis complex (TSC) developed a chest wall fibromatosis and bilateral multifocal renal cell carcinoma (RCC). The fibromatosis tumor was initially resected during infancy but recurred 5 years later. At that time, bilateral RCC was also detected, leading to the resection of the more extensively affected right kidney. In an attempt to avoid bilateral nephrectomies, the patient was treated with the mTOR inhibitor sirolimus. Within 6 months of therapy, the fibromatosis and remaining RCC tumors responded substantially with minimal adverse effects.
Copyright 2010 Wiley-Liss, Inc.
Similar articles
-
Sirolimus and tuberous sclerosis-associated renal angiomyolipomas.Arch Dis Child. 2010 May;95(5):391-2. doi: 10.1136/adc.2009.159210. Arch Dis Child. 2010. PMID: 20457704
-
Antitumoral activity of rapamycin in renal angiomyolipoma associated with tuberous sclerosis complex.Am J Kidney Dis. 2006 Sep;48(3):e27-9. doi: 10.1053/j.ajkd.2006.05.018. Am J Kidney Dis. 2006. PMID: 16931204
-
Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex.Cancer. 1998 Nov 15;83(10):2208-16. Cancer. 1998. PMID: 9827727
-
[A case of renal cell carcinoma associated with tuberous sclerosis].Hinyokika Kiyo. 1999 May;45(5):335-8. Hinyokika Kiyo. 1999. PMID: 10410316 Review. Japanese.
-
Molecular activity of sirolimus and its possible application in tuberous sclerosis treatment.Med Res Rev. 2006 Mar;26(2):160-80. doi: 10.1002/med.20049. Med Res Rev. 2006. PMID: 16329102 Review.
Cited by
-
Rapamycin and rapalogs for tuberous sclerosis complex.Cochrane Database Syst Rev. 2023 Jul 11;7(7):CD011272. doi: 10.1002/14651858.CD011272.pub3. Cochrane Database Syst Rev. 2023. PMID: 37432030 Free PMC article. Review.
-
Tumorigenesis Mechanisms Found in Hereditary Renal Cell Carcinoma: A Review.Genes (Basel). 2022 Nov 15;13(11):2122. doi: 10.3390/genes13112122. Genes (Basel). 2022. PMID: 36421797 Free PMC article. Review.
-
Bilateral Renal Tumors in Children: The First 5 Years' Experience of National Centralization in The Netherlands and a Narrative Review of the Literature.J Clin Med. 2021 Nov 26;10(23):5558. doi: 10.3390/jcm10235558. J Clin Med. 2021. PMID: 34884260 Free PMC article.
-
Exceptional response to everolimus in a novel tuberous sclerosis complex-2 mutation-associated metastatic renal-cell carcinoma.Cold Spring Harb Mol Case Stud. 2018 Apr 2;4(2):a002220. doi: 10.1101/mcs.a002220. Print 2018 Apr. Cold Spring Harb Mol Case Stud. 2018. PMID: 29610387 Free PMC article.
-
[Mesenchymal abdominal tumors in children].Radiologe. 2018 Jan;58(1):3-9. doi: 10.1007/s00117-017-0333-9. Radiologe. 2018. PMID: 29234820 Review. German.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
