Physiological significance of selective degradation of p62 by autophagy
- PMID: 20153326
- DOI: 10.1016/j.febslet.2010.02.017
Physiological significance of selective degradation of p62 by autophagy
Abstract
Autophagy is a highly conserved bulk protein degradation pathway responsible for the turnover of long-lived proteins, disposal of damaged organelles, and clearance of aggregate-prone proteins. Thus, inactivation of autophagy results in cytoplasmic protein inclusions, which are composed of misfolded proteins and excess accumulation of deformed organelles, leading to liver injury, diabetes, myopathy, and neurodegeneration. Although autophagy has been considered non-selective, growing lines of evidence indicate the selectivity of autophagy in sorting vacuolar enzymes and in the removal of aggregate-prone proteins, unwanted organelles and microbes. Such selectivity by autophagy enables diverse cellular regulations, similar to the ubiquitin-proteasome pathway. In this review, we introduce the selective turnover of the ubiquitin- and LC3-binding protein 'p62' through autophagy and discuss its physiological significance.
Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Similar articles
-
A role for ubiquitin in selective autophagy.Mol Cell. 2009 May 15;34(3):259-69. doi: 10.1016/j.molcel.2009.04.026. Mol Cell. 2009. PMID: 19450525 Review.
-
Selective autophagy regulates various cellular functions.Genes Cells. 2010 Sep 1;15(9):923-33. doi: 10.1111/j.1365-2443.2010.01433.x. Epub 2010 Jul 28. Genes Cells. 2010. PMID: 20670274 Review.
-
BAG3 and friends: co-chaperones in selective autophagy during aging and disease.Autophagy. 2011 Jul;7(7):795-8. doi: 10.4161/auto.7.7.15844. Autophagy. 2011. PMID: 21681022
-
Atg8-family interacting motif crucial for selective autophagy.FEBS Lett. 2010 Apr 2;584(7):1379-85. doi: 10.1016/j.febslet.2010.01.018. Epub 2010 Jan 17. FEBS Lett. 2010. PMID: 20083108 Review.
-
Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons.Cell Death Differ. 2007 May;14(5):887-94. doi: 10.1038/sj.cdd.4402120. Epub 2007 Mar 2. Cell Death Differ. 2007. PMID: 17332773 Review.
Cited by
-
Trans-[Pt(amine)Cl2(PPh3)] Complexes Target Mitochondria and Endoplasmic Reticulum in Gastric Cancer Cells.Int J Mol Sci. 2024 Jul 15;25(14):7739. doi: 10.3390/ijms25147739. Int J Mol Sci. 2024. PMID: 39062981 Free PMC article.
-
High frequency electrical stimulation reduces α-synuclein levels and α-synuclein-mediated autophagy dysfunction.Sci Rep. 2024 Jul 12;14(1):16091. doi: 10.1038/s41598-024-64131-3. Sci Rep. 2024. PMID: 38997273 Free PMC article.
-
Tomatidine activates autophagy to improve lung injury and inflammation in sepsis by inhibiting NF-κB and MAPK pathways.Mol Genet Genomics. 2024 Feb 24;299(1):14. doi: 10.1007/s00438-024-02109-6. Mol Genet Genomics. 2024. PMID: 38400847
-
Sestrin1, 2, and 3 are dispensable for female fertility in mice.J Ovarian Res. 2024 Feb 1;17(1):28. doi: 10.1186/s13048-024-01345-z. J Ovarian Res. 2024. PMID: 38297375 Free PMC article.
-
MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.Nat Commun. 2023 Oct 14;14(1):6493. doi: 10.1038/s41467-023-42154-0. Nat Commun. 2023. PMID: 37838725 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
