Evaluation of concentrations of FGF-21 - a new adipocytokine in type 2 diabetes
- PMID: 20205104
Evaluation of concentrations of FGF-21 - a new adipocytokine in type 2 diabetes
Abstract
Introduction: Fibroblast growth factor 21 FGF-21 is a newly discovered adipocytokine which may play a vital role in improvement of insulin sensitivity and pathogenesis of type 2 diabetes. The aim of the study was to assess FGF-21 concentrations in the serum of patients with type 2 diabetes, in comparison to a control group, and evaluate the possible relationships between the studied cytokine and selected clinical and biochemical parameters
Material and methods: The study was conducted in 64 patients with type 2 diabetes, 28 women and 36 men aged 47-70 (median age 61.5), with a median duration of diabetes of 8.5 years. In fasting serum samples, concentrations of glucose, insulin, lipids profile parameters, creatinine, C-reactive protein (CRP), fibrinogen, HbA(1c), adiponectin, and FGF-21 were determined. The control group comprised 20 healthy persons matched for age to the study group, with no disturbances in carbohydrate metabolism: 14 women and 8 men.
Results: We found significant differences concerning the medians of body mass index (BMI) 32.4 kg/m(2) v. 24.1 kg/m(2), p < 0.001; waist circumference 114 cm v. 81 cm, p < 0.001; HDL cholesterol 42.5 mg/dl v. 62.5 mg/dl, p < 0.001; triglyceride (TG) 152 mg/dl v. 99 mg/dl, p < 0.01 in the studied group, in comparison with the control group, respectively. In patients with diabetes, median FGF-21 concentration was 239.9 pg/ml and was significantly greater in comparison to the control group: 112.6 pg/ml p < 0.01. Median adiponectin concentration in patients with type 2 diabetes was significantly lower in comparison to the control group, 7.5 ng/ml v. 9.95 ng/ml, p < 0.05. Significant correlations between FGF-21 concentrations and adiponectin (r = -0.24, p < 0.05), weight (r = 0.27, p < 0.05), glucose (r = 0.27, p < 0.05), HDL cholesterol (r = -0.26, p < 0.05), TG (r = 0.27, p < 005), and estimated glomerular filtration rate (eGFR) (r = -0.28, p < 0.05) were observed. No significant correlations between FGF-21 and parameters of metabolic control, markers of inflammatory status, and insulin resistance, or the presence of vascular complications of diabetes, were noticed.
Conclusions: On the basis of the conducted studies it can be concluded that the greater FGF-21 concentration observed in the examined group of patients with type 2 diabetes may result from a compensatory reaction to metabolic disturbances or tissue resistance to this cytokine. The negative correlation between FGF-21 and eGFR suggests renal elimination of the examined compound. (Pol J Endocrinol 2010; 61 (1): 50-54).
Similar articles
-
Fibroblast growth factor-19: development, analytical characterization and clinical evaluation of a new ELISA test.Scand J Clin Lab Invest. 2008;68(6):501-7. doi: 10.1080/00365510701854967. Scand J Clin Lab Invest. 2008. PMID: 18609104
-
Fıbroblast growth factor 21 and ıts relatıonshıp wıth ınsulın sensıtıvıty ın fırst-degree relatıves of patıents wıth type 2 dıabetes mellıtus.Endokrynol Pol. 2016;67(3):260-4. doi: 10.5603/EP.a2016.0016. Epub 2016 Feb 17. Endokrynol Pol. 2016. PMID: 26884286
-
Fibroblast growth factor-19 levels in type 2 diabetic patients with metabolic syndrome.Ann Clin Lab Sci. 2011 Fall;41(4):390-6. Ann Clin Lab Sci. 2011. PMID: 22166511
-
Plasma adiponectin and insulin resistance in Korean type 2 diabetes mellitus.Yonsei Med J. 2005 Feb 28;46(1):42-50. doi: 10.3349/ymj.2005.46.1.42. Yonsei Med J. 2005. PMID: 15744804 Free PMC article.
-
Positive correlation of serum fibroblast growth factor 23 with peripheral arterial stiffness in kidney transplantation patients.Clin Chim Acta. 2020 Jun;505:9-14. doi: 10.1016/j.cca.2020.02.014. Epub 2020 Feb 15. Clin Chim Acta. 2020. PMID: 32070728 Review.
Cited by
-
The Correlation Between Serum Fibroblast Growth Factor 21 and the Severity and Occurrence of Coronary Artery Disease.Cureus. 2024 Jan 9;16(1):e51924. doi: 10.7759/cureus.51924. eCollection 2024 Jan. Cureus. 2024. PMID: 38333506 Free PMC article.
-
Total serum FGF-21 levels positively relate to visceral adiposity differently from its functional intact form.Front Endocrinol (Lausanne). 2023 Jun 20;14:1159127. doi: 10.3389/fendo.2023.1159127. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37409233 Free PMC article.
-
Current Toolset in Predicting Acute Coronary Thrombotic Events: The "Vulnerable Plaque" in a "Vulnerable Patient" Concept.Life (Basel). 2023 Mar 4;13(3):696. doi: 10.3390/life13030696. Life (Basel). 2023. PMID: 36983851 Free PMC article. Review.
-
Is serum fibroblast growth factor 21 associated with the severity or presence of coronary artery disease?J Med Biochem. 2022 Apr 8;41(2):162-167. doi: 10.5937/jomb0-30191. J Med Biochem. 2022. PMID: 35510201 Free PMC article.
-
A review of fibroblast growth factor 21 in diabetic cardiomyopathy.Heart Fail Rev. 2019 Nov;24(6):1005-1017. doi: 10.1007/s10741-019-09809-x. Heart Fail Rev. 2019. PMID: 31175491 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous