The steroid receptor RNA activator protein is recruited to promoter regions and acts as a transcriptional repressor
- PMID: 20398657
- DOI: 10.1016/j.febslet.2010.04.022
The steroid receptor RNA activator protein is recruited to promoter regions and acts as a transcriptional repressor
Abstract
Products of the steroid receptor RNA activator (SRA1) gene have the unusual property to function both at the RNA and the protein levels. SRA-RNA has long been known to increase the activity of multiple nuclear receptors. It has more recently been proposed than steroid receptor RNA activator protein (SRAP) also modulates steroid receptors activity. Herein, we show for the first time that SRAP physically interacts with multiple transcription factors and is recruited to specific promoter regions. Artificially recruiting SRAP to the promoter of a luciferase reporter gene under the control of the strong transcriptional activator VP16 leads to a decrease in transcription. Altogether we propose that SRAP could be a new transcriptional regulator, able to function as a repressor through direct association with promoters.
Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Similar articles
-
Steroid Receptor RNA Activator - A nuclear receptor coregulator with multiple partners: Insights and challenges.Biochimie. 2011 Nov;93(11):1966-72. doi: 10.1016/j.biochi.2011.07.004. Epub 2011 Jul 27. Biochimie. 2011. PMID: 21807064 Review.
-
Steroid Receptor RNA Activator bi-faceted genetic system: Heads or Tails?Biochimie. 2011 Nov;93(11):1973-80. doi: 10.1016/j.biochi.2011.07.002. Epub 2011 Jul 12. Biochimie. 2011. PMID: 21771633 Review.
-
The protein encoded by the functional steroid receptor RNA activator is a new modulator of ER alpha transcriptional activity.FEBS Lett. 2010 Mar 19;584(6):1174-80. doi: 10.1016/j.febslet.2010.02.024. Epub 2010 Feb 11. FEBS Lett. 2010. PMID: 20153324
-
The RNA coregulator SRA, its binding proteins and nuclear receptor signaling activity.IUBMB Life. 2008 Mar;60(3):159-64. doi: 10.1002/iub.22. IUBMB Life. 2008. PMID: 18380007 Review.
-
Steroid receptor RNA activator (SRA1): unusual bifaceted gene products with suspected relevance to breast cancer.Nucl Recept Signal. 2007 Aug 3;5:e006. doi: 10.1621/nrs.05006. Nucl Recept Signal. 2007. PMID: 17710122 Free PMC article. Review.
Cited by
-
Zinc deficiency is associated with the development of ovarian endometrial cysts.Am J Cancer Res. 2023 Mar 15;13(3):1049-1066. eCollection 2023. Am J Cancer Res. 2023. PMID: 37034203 Free PMC article.
-
GnRH Deficient Patients With Congenital Hypogonadotropic Hypogonadism: Novel Genetic Findings in ANOS1, RNF216, WDR11, FGFR1, CHD7, and POLR3A Genes in a Case Series and Review of the Literature.Front Endocrinol (Lausanne). 2020 Aug 28;11:626. doi: 10.3389/fendo.2020.00626. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 32982993 Free PMC article.
-
New Insights Into the Long Non-coding RNA SRA: Physiological Functions and Mechanisms of Action.Front Med (Lausanne). 2018 Sep 6;5:244. doi: 10.3389/fmed.2018.00244. eCollection 2018. Front Med (Lausanne). 2018. PMID: 30238005 Free PMC article. Review.
-
cncRNAs: Bi-functional RNAs with protein coding and non-coding functions.Semin Cell Dev Biol. 2015 Dec;47-48:40-51. doi: 10.1016/j.semcdb.2015.10.024. Epub 2015 Oct 20. Semin Cell Dev Biol. 2015. PMID: 26498036 Free PMC article. Review.
-
Identification and expression of an encoding steroid receptor coactivator (SRA) in amphioxus (Branchiostoma japonicum).Mol Biol Rep. 2013 Nov;40(11):6385-95. doi: 10.1007/s11033-013-2753-6. Epub 2013 Sep 25. Mol Biol Rep. 2013. PMID: 24065542
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
