Type 2 diabetes, related conditions, in relation and dementia: an opportunity for prevention?
- PMID: 20413862
- DOI: 10.3233/JAD-2010-091687
Type 2 diabetes, related conditions, in relation and dementia: an opportunity for prevention?
Abstract
This manuscript provides a comprehensive review of the epidemiologic evidence linking type 2 diabetes (T2D) and its precursor conditions, elevated adiposity and hyperinsulinemia, to dementia. The mechanisms relating these conditions to dementia may be vascular and non-vascular. Elevated adiposity in middle age is related to a higher risk of dementia but the data on this association in old age is conflicting. Several studies have shown that hyperinsulinemia, a consequence of higher adiposity and insulin resistance, is also related to a higher risk of dementia, including late onset Alzheimer's disease (LOAD). Studies have consistently shown a relation of T2D with higher dementia risk, but the associations are stronger for vascular dementia compared to LOAD. A large proportion of the world population may be at increased risk of dementia given the trends for increasing prevalence of overweight, obesity, hyperinsulinemia, and T2D. However, these associations may present a unique opportunity for prevention and treatment of dementia. There are several known modalities that are effective in the prevention and T2D and the reduction of hyperinsulinemia including lifestyle interventions, metformin, thiazolideniodones, and acarbose. Several studies in the prevention and treatment of T2D are currently measuring cognitive outcomes and will provide information on whether T2D treatment and prevention can prevent cognitive decline and dementia.
Similar articles
-
Diabetes, related conditions, and dementia.J Neurol Sci. 2010 Dec 15;299(1-2):35-8. doi: 10.1016/j.jns.2010.08.063. J Neurol Sci. 2010. PMID: 20888602 Free PMC article. Review.
-
Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective.Eur J Pharmacol. 2008 May 6;585(1):119-29. doi: 10.1016/j.ejphar.2008.02.048. Epub 2008 Mar 4. Eur J Pharmacol. 2008. PMID: 18384771 Free PMC article. Review.
-
Adiposity, type 2 diabetes, and Alzheimer's disease.J Alzheimers Dis. 2009;16(4):693-704. doi: 10.3233/JAD-2009-1022. J Alzheimers Dis. 2009. PMID: 19387106 Free PMC article. Review.
-
Insulin resistance in the brain: an old-age or new-age problem?Biochem Pharmacol. 2012 Sep 15;84(6):737-45. doi: 10.1016/j.bcp.2012.05.007. Epub 2012 May 16. Biochem Pharmacol. 2012. PMID: 22634336 Review.
-
Caffeine, diabetes, cognition, and dementia.J Alzheimers Dis. 2010;20 Suppl 1:S143-50. doi: 10.3233/JAD-2010-091228. J Alzheimers Dis. 2010. PMID: 20182038 Review.
Cited by
-
Potential Role of Glucagon-like Peptide-1 Receptor Agonists in the Treatment of Cognitive Decline and Dementia in Diabetes Mellitus.Int J Mol Sci. 2023 Jul 11;24(14):11301. doi: 10.3390/ijms241411301. Int J Mol Sci. 2023. PMID: 37511061 Free PMC article. Review.
-
Review of Advanced Drug Trials Focusing on the Reduction of Brain Beta-Amyloid to Prevent and Treat Dementia.J Exp Pharmacol. 2022 Oct 30;14:331-352. doi: 10.2147/JEP.S265626. eCollection 2022. J Exp Pharmacol. 2022. PMID: 36339394 Free PMC article. Review.
-
Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics.Adv Drug Deliv Rev. 2022 Nov;190:114537. doi: 10.1016/j.addr.2022.114537. Epub 2022 Sep 14. Adv Drug Deliv Rev. 2022. PMID: 36115494 Free PMC article. Review.
-
Insulin and Its Key Role for Mitochondrial Function/Dysfunction and Quality Control: A Shared Link between Dysmetabolism and Neurodegeneration.Biology (Basel). 2022 Jun 20;11(6):943. doi: 10.3390/biology11060943. Biology (Basel). 2022. PMID: 35741464 Free PMC article. Review.
-
The association between sodium-glucose cotransporter 2 inhibitors and incident dementia: A nationwide population-based longitudinal cohort study.Diab Vasc Dis Res. 2022 May-Jun;19(3):14791641221098168. doi: 10.1177/14791641221098168. Diab Vasc Dis Res. 2022. PMID: 35549730 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical