Homing peptides as targeted delivery vehicles
- PMID: 20657951
- DOI: 10.1039/c0ib00013b
Homing peptides as targeted delivery vehicles
Abstract
Each normal organ and pathological condition appear to contain organ- or disease-specific molecular tags on its vasculature, which constitute a vascular "zip code" system. In vivo phage display has been exploited to profile this vascular heterogeneity and a number of peptides that home specifically to various normal organs or pathological conditions have been identified. These peptides have been used for targeted delivery of oligonucleotides, drugs, imaging agents, inorganic nanoparticles, liposomes, and viruses. Identification of the receptor molecules for the homing peptides has revealed novel biomarkers for target organs. In tumors many of these receptors seem to play a functional role in tumor angiogenesis. Recently, tumor homing peptides have entered clinical trials. Results from several Phase I and II trials have been reported, and a number of trials are currently ongoing or recruiting patients. In these trials no dose-limiting toxicity has occurred and all combinations of peptide-targeted therapies have been well tolerated.
Similar articles
-
Vascular-homing peptides for targeted drug delivery and molecular imaging: meeting the clinical challenges.Biochim Biophys Acta. 2014 Aug;1846(1):1-12. doi: 10.1016/j.bbcan.2014.03.004. Epub 2014 Apr 1. Biochim Biophys Acta. 2014. PMID: 24704283 Review.
-
Identification of homing peptides using the in vivo phage display technology.Methods Mol Biol. 2011;683:401-15. doi: 10.1007/978-1-60761-919-2_29. Methods Mol Biol. 2011. PMID: 21053146
-
Mouse thymus targeted peptide isolated by in vivo phage display can inhibit bioactivity of thymus output in vivo.J Biomol Screen. 2008 Dec;13(10):968-74. doi: 10.1177/1087057108326537. Epub 2008 Oct 31. J Biomol Screen. 2008. PMID: 18978306
-
Peptide targeting of tumor lymph vessels.Ann N Y Acad Sci. 2008;1131:37-43. doi: 10.1196/annals.1413.003. Ann N Y Acad Sci. 2008. PMID: 18519957 Review.
-
Tumour-homing peptides: tools for targeting, imaging and destruction.Biochem Soc Trans. 2007 Aug;35(Pt 4):780-3. doi: 10.1042/BST0350780. Biochem Soc Trans. 2007. PMID: 17635147 Review.
Cited by
-
Review of Spider Silk Applications in Biomedical and Tissue Engineering.Biomimetics (Basel). 2024 Mar 11;9(3):169. doi: 10.3390/biomimetics9030169. Biomimetics (Basel). 2024. PMID: 38534854 Free PMC article. Review.
-
Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics.Nanomaterials (Basel). 2023 Sep 1;13(17):2476. doi: 10.3390/nano13172476. Nanomaterials (Basel). 2023. PMID: 37686984 Free PMC article. Review.
-
LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles.Autophagy. 2023 Nov;19(11):2837-2852. doi: 10.1080/15548627.2023.2235196. Epub 2023 Jul 21. Autophagy. 2023. PMID: 37469132 Free PMC article. Review.
-
Peptide-drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?Acta Pharm Sin B. 2023 Feb;13(2):498-516. doi: 10.1016/j.apsb.2022.07.020. Epub 2022 Aug 3. Acta Pharm Sin B. 2023. PMID: 36873165 Free PMC article. Review.
-
Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo.Pharmaceutics. 2022 Dec 27;15(1):92. doi: 10.3390/pharmaceutics15010092. Pharmaceutics. 2022. PMID: 36678721 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
