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Comparative Study
. 2010 Nov;89(11):1241-6.
doi: 10.1177/0022034510375830. Epub 2010 Aug 25.

Oxidative stress, systemic inflammation, and severe periodontitis

F D'Aiuto  1 , L Nibali, M Parkar, K Patel, J Suvan, N Donos
Affiliations
Comparative Study

Oxidative stress, systemic inflammation, and severe periodontitis

F D'Aiuto et al. J Dent Res. 2010 Nov.

Abstract

Periodontal infections have been associated with a state of chronic inflammation. To ascertain whether severe periodontitis and its treatment are associated with oxidative stress, we recruited 145 cases (periodontitis) and 56 controls in a case-control study. A further pilot intervention study of 14 cases (periodontal therapy) was performed. Blood samples were taken at baseline (case-control) and 1, 3, 5, 7, and 30 days after treatment (intervention). Diacron-reactive oxygen metabolites (D-ROM), anti-oxidant potential, C-reactive protein (CRP), interleukin-6, and lipid profiles were determined with high-sensitivity assays in serum. Patients with severe periodontitis exhibited higher D-ROM levels (P < 0.001) and lower total anti-oxidant capacity (P < 0.001) compared with healthy control individuals. These findings were independent of age, gender, smoking habits, ethnicity, and standard lipids differences. D-ROM levels were positively correlated with CRP (R = 0.4, P < 0.001) and clinical periodontal parameters (R = 0.20, P < 0.05). Acute increases of D-ROM (P < 0.01) were observed following periodontal therapy. Analysis of these data suggests a positive association between severe periodontitis and oxidative stress.

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Figures

Figure 1.
Figure 1.
Box and whiskers plots of Oxidative Stress. (A) D-ROM (UCarr units) and anti-oxidant (B) BAP (mmol/L) measurements between individuals with periodontitis compared with control individuals. (C) D-ROM (UCarr units) and anti-oxidant (D) BAP (mmol/L) measurements among individuals with diagnosis of chronic (n = 122) or aggressive (n = 23) periodontitis compared with control individuals (n = 56). Boxes refer to the 25th (bottom) and 75th (up) percentiles, and the median is the large horizontal line; fences refer to the 10th (lower) and 90th (upper) percentiles, respectively. Open circles represent outliers.
Figure 2.
Figure 2.
Scatter plot of serum D-ROM (UCarr) against (A) CRP levels (R = 0.4, P < 0.001), and (B) severity of periodontitis (Probing pocket depths, mm) (R = 0.2, P = 0.04) by Spearman’s rank correlation test.
Figure 3.
Figure 3.
Mean values (standard errors) of serum (A) D-ROM (UCarr) and (B) BAP (mmol/L) before (D0), 1 (D1), 3 (D3), 5 (D5), 7 (D7), and 30 (D30) days after intensive periodontal therapy. Asterisks refer to statistically significant difference (P < 0.05) between visits as computed with analysis of variance for repeated measures (post hoc comparison with Bonferroni corrections).
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