The role of serotonin in respiratory function and dysfunction
- PMID: 20801236
- PMCID: PMC2993113
- DOI: 10.1016/j.resp.2010.08.017
The role of serotonin in respiratory function and dysfunction
Abstract
Serotonin (5-HT) is a neuromodulator-transmitter influencing global brain function. Past and present findings illustrate a prominent role for 5-HT in the modulation of ponto-medullary autonomic circuits. 5-HT is also involved in the control of neurotrophic processes during pre- and postnatal development of neural circuits. The functional implications of 5-HT are particularly illustrated in the alterations to the serotonergic system, as seen in a wide range of neurological disorders. This article reviews the role of 5-HT in the development and control of respiratory networks in the ponto-medullary brainstem. The review further examines the role of 5-HT in breathing disorders occurring at different stages of life, in particular, the neonatal neurodevelopmental diseases such as Rett, sudden infant death and Prader-Willi syndromes, adult diseases such as sleep apnoea and mental illness linked to neurodegeneration.
Crown Copyright © 2010. Published by Elsevier B.V. All rights reserved.
Figures
![Fig. 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2993113/bin/nihms243615f1.gif)
![Fig. 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2993113/bin/nihms243615f2.gif)
![Fig. 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2993113/bin/nihms243615f3.gif)
![Fig. 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2993113/bin/nihms243615f4.gif)
Similar articles
-
Abnormalities of serotonergic neurotransmission in animal models of SUDEP.Epilepsy Behav. 2017 Jun;71(Pt B):174-180. doi: 10.1016/j.yebeh.2015.06.008. Epub 2015 Aug 10. Epilepsy Behav. 2017. PMID: 26272185 Free PMC article. Review.
-
The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis.J Chem Neuroanat. 2011 Jul;41(4):182-99. doi: 10.1016/j.jchemneu.2011.05.004. Epub 2011 May 27. J Chem Neuroanat. 2011. PMID: 21640183 Free PMC article. Review.
-
Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons.Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1783-96. doi: 10.1152/ajpregu.00122.2009. Epub 2009 Apr 15. Am J Physiol Regul Integr Comp Physiol. 2009. PMID: 19369586 Free PMC article.
-
Necdin plays a role in the serotonergic modulation of the mouse respiratory network: implication for Prader-Willi syndrome.J Neurosci. 2008 Feb 13;28(7):1745-55. doi: 10.1523/JNEUROSCI.4334-07.2008. J Neurosci. 2008. PMID: 18272695 Free PMC article.
-
Subtle autonomic and respiratory dysfunction in sudden infant death syndrome associated with serotonergic brainstem abnormalities: a case report.J Neuropathol Exp Neurol. 2005 Aug;64(8):689-94. doi: 10.1097/01.jnen.0000174334.27708.43. J Neuropathol Exp Neurol. 2005. PMID: 16106217
Cited by
-
Fischer's oligopeptide ratio in ischemic hypoxia: prophylactic amendment of sophoretin and melatonin supplementation.Future Sci OA. 2024 May 20;10(1):FSO911. doi: 10.2144/fsoa-2023-0117. eCollection 2024. Future Sci OA. 2024. PMID: 38827802 Free PMC article.
-
Impact of Serotonergic 5HT1A and 5HT2A Receptor Activation on the Respiratory Response to Hypercapnia in a Rat Model of Parkinson's Disease.Int J Mol Sci. 2024 Apr 17;25(8):4403. doi: 10.3390/ijms25084403. Int J Mol Sci. 2024. PMID: 38673988 Free PMC article.
-
A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders.J Cannabis Res. 2024 Mar 18;6(1):14. doi: 10.1186/s42238-024-00222-2. J Cannabis Res. 2024. PMID: 38494488 Free PMC article. Review.
-
Male histone deacetylase 6 (HDAC6) knockout mice have enhanced ventilatory responses to hypoxic challenge.Front Physiol. 2024 Feb 6;14:1332810. doi: 10.3389/fphys.2023.1332810. eCollection 2023. Front Physiol. 2024. PMID: 38384929 Free PMC article.
-
Revisiting the Role of Serotonin in Sleep-Disordered Breathing.Int J Mol Sci. 2024 Jan 25;25(3):1483. doi: 10.3390/ijms25031483. Int J Mol Sci. 2024. PMID: 38338762 Free PMC article. Review.
References
-
- Abad VC, Guilleminault C. Pharmacological management of sleep apnoea. Expert Opin Pharmacother. 2007;7:11–23. - PubMed
-
- Aghajanian GK, Sprouse JS, Sheldon P, Rasmussen K. Electrophysiology of the central serotonin system: receptor subtypes and transducer mechanisms. Ann N Y Acad Sci. 1990;600:93–103. - PubMed
-
- Akefeldt A, Ekman R, Gillberg C, Månsson JE. Cerebrospinal fluid monoamines in Prader-Willi syndrome. Biol Psychiatry. 1998;44:1321–1328. - PubMed
-
- Alenina N, Bashammakh S, Bader M. Specification and differentiation of serotonergic neurons. Stem Cell Rev. 2006;2:5–10. - PubMed
-
- Amiel J, Dubreuil V, Ramanantsoa N, Fortin G, Gallego J, Brunet JF, Goridis C. PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models. Respir Physiol Neurobiol. 2009;168:125–132. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous