DCs in immune tolerance in steady-state conditions
- PMID: 20941606
- DOI: 10.1007/978-1-60761-869-0_8
DCs in immune tolerance in steady-state conditions
Abstract
Dendritic cells (DCs) are antigen-presenting cells (APCs) characterized by a unique capacity to stimulate naïve T cells and initiate primary immune responses. Recent studies suggest that DCs are also involved in the induction of immunological tolerance in peripheral tissues under steady-state conditions by maintaining the homeostasis of self-reactive CD4(+)Foxp3(+)naturally occurring thymic-derived regulatory T cells (nT(regs)) and de novo generation of antigen-specific CD4(+)Foxp3(+)inducible regulatory T cells (iT(regs)). We demonstrate here the impact of CD11(+)DCs on the antigen-specific differentiation of CD4(+)Foxp3(+)iT(regs) from CD4(+)Foxp3(-)T cells under steady-state and inflammatory conditions. CD11c(+)DCs promoted the transforming growth factor (TGF)-β1-mediated conversion of CD4(+)Foxp3(-)T cells into CD4(+)Foxp3(+)iT(regs) in vitro, while stimulation of CD11c(+)DCs with CpG oligodeoxynucleotide (ODN) abrogated this conversion. Furthermore, antigen-specific generation of CD4(+)Foxp3(+)iT(regs) required the function of CD11(+)DCs under steady-state conditions, whereas such conversion was severely abolished under inflammatory conditions. Thus, these results suggest the crucial role of DCs in the antigen-specific de novo conversion of CD4(+)Foxp3(-)T cells into CD4(+)Foxp3(+)iT(regs) under steady-state conditions, thereby leading to the establishment of peripheral immune tolerance.
Similar articles
-
Regulation of the tolerogenic function of steady-state DCs.Eur J Immunol. 2014 Apr;44(4):927-33. doi: 10.1002/eji.201343862. Epub 2014 Mar 20. Eur J Immunol. 2014. PMID: 24652744 Review.
-
Dendritic cells and B cells cooperate in the generation of CD4(+)CD25(+)FOXP3(+) allogeneic T cells.Transplant Proc. 2010 Jan-Feb;42(1):371-5. doi: 10.1016/j.transproceed.2009.12.044. Transplant Proc. 2010. PMID: 20172352
-
CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells.Gut. 2009 Feb;58(2):211-9. doi: 10.1136/gut.2008.151720. Epub 2008 Oct 2. Gut. 2009. PMID: 18832523
-
Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells including suppressors of alloreactivity.Immunol Rev. 2006 Aug;212:314-29. doi: 10.1111/j.0105-2896.2006.00422.x. Immunol Rev. 2006. PMID: 16903923 Review.
-
Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells.Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1047-55. doi: 10.1167/iovs.05-0110. Invest Ophthalmol Vis Sci. 2006. PMID: 16505040
Cited by
-
Prognostic Role of Combined EGFR and Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma.Front Oncol. 2022 Jul 25;12:885236. doi: 10.3389/fonc.2022.885236. eCollection 2022. Front Oncol. 2022. PMID: 35957892 Free PMC article.
-
Adoptive transfer of dendritic cells expressing CD11c reduces the immunological response associated with experimental colitis in BALB/c mice.PLoS One. 2018 May 8;13(5):e0196994. doi: 10.1371/journal.pone.0196994. eCollection 2018. PLoS One. 2018. PMID: 29738575 Free PMC article.
-
[Study on the immune functions of dendritic cells regulated by histone deacetylase inhibitor Belinostat].Zhonghua Xue Ye Xue Za Zhi. 2018 Jan 14;39(1):41-46. doi: 10.3760/cma.j.issn.0253-2727.2018.01.009. Zhonghua Xue Ye Xue Za Zhi. 2018. PMID: 29551032 Free PMC article. Chinese.
-
Regulatory dendritic cells for immunotherapy in immunologic diseases.Front Immunol. 2014 Jan 31;5:7. doi: 10.3389/fimmu.2014.00007. eCollection 2014. Front Immunol. 2014. PMID: 24550907 Free PMC article. Review.
-
Tolerogenic vaccines for Multiple sclerosis.Hum Vaccin Immunother. 2013 May;9(5):1032-8. doi: 10.4161/hv.23685. Epub 2013 Jan 28. Hum Vaccin Immunother. 2013. PMID: 23357858 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous