Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Nov;10(11):745-59.
doi: 10.1038/nrc2945. Epub 2010 Oct 22.

The renin-angiotensin system and cancer: old dog, new tricks

Amee J George  1 , Walter G Thomas, Ross D Hannan
Affiliations
Review

The renin-angiotensin system and cancer: old dog, new tricks

Amee J George et al. Nat Rev Cancer. 2010 Nov.

Abstract

For cancers to develop, sustain and spread, the appropriation of key homeostatic physiological systems that influence cell growth, migration and death, as well as inflammation and the expansion of vascular networks are required. There is accumulating molecular and in vivo evidence to indicate that the expression and actions of the renin-angiotensin system (RAS) influence malignancy and also predict that RAS inhibitors, which are currently used to treat hypertension and cardiovascular disease, might augment cancer therapies. To appreciate this potential hegemony of the RAS in cancer, an expanded comprehension of the cellular actions of this system is needed, as well as a greater focus on translational and in vivo research.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Exp Physiol. 2008 May;93(5):658-64 - PubMed
    1. Cancer Res. 2002 Nov 1;62(21):6329-36 - PubMed
    1. Circulation. 2002 Jan 29;105(4):530-6 - PubMed
    1. Genes Dev. 2001 Jan 1;15(1):50-65 - PubMed
    1. Curr Opin Cell Biol. 2004 Apr;16(2):162-8 - PubMed

Publication types

MeSH terms

LinkOut - more resources

-