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. 2010 Nov 18;8(5):433-44.
doi: 10.1016/j.chom.2010.10.009.

Entrapment of intracytosolic bacteria by septin cage-like structures

Serge Mostowy  1 , Matteo Bonazzi, Mélanie Anne Hamon, To Nam Tham, Adeline Mallet, Mickaël Lelek, Edith Gouin, Caroline Demangel, Roland Brosch, Christophe Zimmer, Anna Sartori, Makoto Kinoshita, Marc Lecuit, Pascale Cossart
Affiliations
Free article

Entrapment of intracytosolic bacteria by septin cage-like structures

Serge Mostowy et al. Cell Host Microbe. .
Free article

Abstract

Actin-based motility is used by various pathogens for dissemination within and between cells. Yet host factors restricting this process have not been identified. Septins are GTP-binding proteins that assemble as filaments and are essential for cell division. However, their role during interphase has remained elusive. Here, we report that septin assemblies are recruited to different bacteria that polymerize actin. We observed that intracytosolic Shigella either become compartmentalized in septin cage-like structures or form actin tails. Inactivation of septin caging increases the number of Shigella with actin tails and enhances cell-to-cell spread. TNF-α, a host cytokine produced upon Shigella infection, stimulates septin caging and restricts actin tail formation and cell-to-cell spread. Finally, we show that septin cages entrap bacteria targeted to autophagy. Together, these results reveal an unsuspected mechanism of host defense that restricts dissemination of invasive pathogens.

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Comment in

  • Caging targets for destruction.
    Stamm LM, Heller DM, Goldberg MB. Stamm LM, et al. Cell Host Microbe. 2010 Nov 18;8(5):391-3. doi: 10.1016/j.chom.2010.10.010. Cell Host Microbe. 2010. PMID: 21075349

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