Exome sequencing reveals VCP mutations as a cause of familial ALS
- PMID: 21145000
- PMCID: PMC3032425
- DOI: 10.1016/j.neuron.2010.11.036
Exome sequencing reveals VCP mutations as a cause of familial ALS
Erratum in
- Neuron. 2011 Jan 27;69(2):397
Abstract
Using exome sequencing, we identified a p.R191Q amino acid change in the valosin-containing protein (VCP) gene in an Italian family with autosomal dominantly inherited amyotrophic lateral sclerosis (ALS). Mutations in VCP have previously been identified in families with Inclusion Body Myopathy, Paget disease, and Frontotemporal Dementia (IBMPFD). Screening of VCP in a cohort of 210 familial ALS cases and 78 autopsy-proven ALS cases identified four additional mutations including a p.R155H mutation in a pathologically proven case of ALS. VCP protein is essential for maturation of ubiquitin-containing autophagosomes, and mutant VCP toxicity is partially mediated through its effect on TDP-43 protein, a major constituent of ubiquitin inclusions that neuropathologically characterize ALS. Our data broaden the phenotype of IBMPFD to include motor neuron degeneration, suggest that VCP mutations may account for ∼1%-2% of familial ALS, and provide evidence directly implicating defects in the ubiquitination/protein degradation pathway in motor neuron degeneration.
Copyright © 2010 Elsevier Inc. All rights reserved.
Conflict of interest statement
None of the other authors have any conflicts of interest.
Figures
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Comment in
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Capturing VCP: another molecular piece in the ALS jigsaw puzzle.Neuron. 2010 Dec 9;68(5):812-4. doi: 10.1016/j.neuron.2010.11.040. Neuron. 2010. PMID: 21144996
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