Cetuximab and panitumumab in KRAS wild-type colorectal cancer: a meta-analysis
- PMID: 21286919
- DOI: 10.1007/s00384-011-1149-0
Cetuximab and panitumumab in KRAS wild-type colorectal cancer: a meta-analysis
Abstract
Background: Anti-epidermal growth factor receptor monoclonal antibodies (panitumumab [P] and cetuximab [C]) are approved and effective only in KRAS wild-type patients with advanced colorectal cancer. The purpose of our meta-analysis is to evaluate the real effects of C and P in KRAS wild-type patients treated in randomized trials.
Patients and methods: Eligible studies included prospective, randomized, and controlled trials in which either C or P had been added to standard antineoplastic therapy or best supportive care and data for KRAS wild-type patients only had been calculated. Six thousand three hundred ninety-five patients' tumor samples have been analyzed (total wild-type n = 3,254; experimental arm n = 1,608; control arm n = 1,646). Relative risks (RRs) with 95% confidence intervals (CIs) for response rate were calculated, as well as hazard ratios (HRs)for progression-free survival (PFS) and overall survival.
Results: The overall RR of response rate is 1.69 (p = 0.003) in all trials. The overall HRs for PFS and survival are 0.65 (p = 0.0006) and 0.84 (p = 0.03), respectively, and both are significant. The HRs for PFS and survival in C trials are 0.64 and 0.79, respectively, and 0.65 and 0.87, respectively, in P trials, although only the results achieved in P trials are significant (p = 0.0007 and p = 0.03). Both response rate (RR = 10.94) and PFS (HR = 0.51) have increased more in pretreated patients than in first-line trials.
Conclusion: The addition of anti-EGFR monoclonal antibodies to standard anticancer therapy in KRAS wild-type colorectal cancer showed an overall significantly increased risk of objective response rate and increased progression-free and overall survival. Only the results achieved in P randomized trials are significant, and the strongest results have been achieved in pretreated patients.
Similar articles
-
Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of randomized, controlled trials.Ann Oncol. 2015 Jan;26(1):13-21. doi: 10.1093/annonc/mdu378. Epub 2014 Aug 12. Ann Oncol. 2015. PMID: 25115304 Review.
-
No survival benefit from adding cetuximab or panitumumab to oxaliplatin-based chemotherapy in the first-line treatment of metastatic colorectal cancer in KRAS wild type patients: a meta-analysis.PLoS One. 2012;7(11):e50925. doi: 10.1371/journal.pone.0050925. Epub 2012 Nov 30. PLoS One. 2012. PMID: 23226426 Free PMC article.
-
Resectability and outcome with anti-EGFR agents in patients with KRAS wild-type colorectal liver-limited metastases: a meta-analysis.Int J Colorectal Dis. 2012 Aug;27(8):997-1004. doi: 10.1007/s00384-012-1438-2. Epub 2012 Feb 23. Int J Colorectal Dis. 2012. PMID: 22358385
-
Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab.Oncologist. 2012;17(1):14. doi: 10.1634/theoncologist.2011-0452. Epub 2011 Dec 30. Oncologist. 2012. PMID: 22210091 Free PMC article. Clinical Trial.
-
Systematic review: Anti-epidermal growth factor receptor treatment effect modification by KRAS mutations in advanced colorectal cancer.Ann Intern Med. 2011 Jan 4;154(1):37-49. doi: 10.7326/0003-4819-154-1-201101040-00006. Ann Intern Med. 2011. PMID: 21200037 Review.
Cited by
-
The heterogeneity effect of surveillance intervals on progression free survival.J Appl Stat. 2022 Nov 14;51(4):646-663. doi: 10.1080/02664763.2022.2145272. eCollection 2024. J Appl Stat. 2022. PMID: 38414801 Free PMC article.
-
Computational insights into the stereo-selectivity of catechins for the inhibition of the cancer therapeutic target EGFR kinase.Front Pharmacol. 2024 Jan 11;14:1231671. doi: 10.3389/fphar.2023.1231671. eCollection 2023. Front Pharmacol. 2024. PMID: 38273823 Free PMC article.
-
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies.Signal Transduct Target Ther. 2023 Dec 18;8(1):455. doi: 10.1038/s41392-023-01705-z. Signal Transduct Target Ther. 2023. PMID: 38105263 Free PMC article. Review.
-
Bispecific antibodies in cancer therapy: Target selection and regulatory requirements.Acta Pharm Sin B. 2023 Sep;13(9):3583-3597. doi: 10.1016/j.apsb.2023.05.023. Epub 2023 May 23. Acta Pharm Sin B. 2023. PMID: 37719370 Free PMC article. Review.
-
Dendrimers for cancer immunotherapy: Avidity-based drug delivery vehicles for effective anti-tumor immune response.Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 Mar;14(2):e1752. doi: 10.1002/wnan.1752. Epub 2021 Aug 19. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022. PMID: 34414690 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous