Brain serotonergic circuitries
- PMID: 21319493
- PMCID: PMC3181988
- DOI: 10.31887/DCNS.2010.12.4/ycharnay
Brain serotonergic circuitries
Abstract
Brain serotonergic circuitries interact with other neurotransmitter systems on a multitude of different molecular levels. In humans, as in other mammalian species, serotonin (5-HT) plays a modulatory role in almost every physiological function. Furthermore, serotonergic dysfunction is thought to be implicated in several psychiatric and neurodegenerative disorders. We describe the neuroanatomy and neurochemistry of brain serotonergic circuitries. The contribution of emergent in vivo imaging methods to the regional localization of binding site receptors and certain aspects of their functional connectivity in correlation to behavior is also discussed. 5-HT cell bodies, mainly localized in the raphe nuclei, send axons to almost every brain region. It is argued that the specificity of the local chemocommunication between 5-HT and other neuronal elements mainly depends on mechanisms regulating the extracellular concentration of 5-HT the diversity of high-affinity membrane receptors, and their specific transduction modalities.
Los circuitos serotoninérgicos cerebrales interactúan con otros sistemas de neurotransmisión en una infinidad de diferentes niveles moleculares. En humanos, como también en otras especies de mamíferos, la serotonina (5HT) tiene un papel modulador en casi todas las funciones fisiológicas. Además se postula que la disfunción serotoninérgica participa en diversos trastornos psiquiátricos y neurodegenerativos. Se describe la neuroanatomía y la neuroquímica de los circuitos serotoninérgicos cerebrales. También se discute la contribución de novedosos métodos de imágenes in vivo para la localización regional de sitios de unión de receptores y ciertos aspectos de su conectividad funcional en relación con la conducta. Los cuerpos de 5-HT, localizados principalmente en los núcleos del rafe, envían axones a casi todas las regiones cerebrales. Se argumenta que la especificidad de la comunicación química local entre 5-HT y otros elementos neuronales depende principalmente de mecanismos que regulan la concentración extracelular de 5-HT, de la diversidad de receptores de membrana de alta afinidad y de sus modalidades de transducción específicas.
Les circuits sérotoninergiques centraux sont le théâtre d'une myriade d'interactions moléculaires dévolues à leur communication. Chez l'homme comme chez les autres espèces, la sérotonine (5-HT) joue un rôle modulateur dans la presque totalité des fonctions physiologiques. De plus, un dysfonctionnement des systèmes sérotoninergiques est présumé impliqué dans diverses pathologies psychiatriques et neurodégénératives. Nous décrivons en détail les circuits sérotoninergiques centraux à partir d'études neuroanatomiques postmortem. La contribution des approches modernes in vivo permettant la localisation régionale de récepteurs et certains aspects de leur fonctionnalité corrélée à des comportements sont aussi discutées. Les corps cellulaires à 5-HT principalement localisés dans les noyaux des raphés projettent des axones dans la plupart des régions du cerveau. Ainsi la spécificité de la communication chimique locale établie entre les éléments neuronaux à 5-HT et les autres dépend de mécanismes régulant la concentration extracellulaire en 5-HT, de la diversité des récepteurs membranaires de haute affinité et de leurs modalités de transduction.
Figures
![Figure 1.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3181988/bin/DialoguesClinNeurosci-12-471-g001.gif)
![Figure 2.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3181988/bin/DialoguesClinNeurosci-12-471-g002.gif)
![Figure 3.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3181988/bin/DialoguesClinNeurosci-12-471-g003.gif)
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