Imaging retinal mosaics in the living eye
- PMID: 21390064
- PMCID: PMC3178316
- DOI: 10.1038/eye.2010.221
Imaging retinal mosaics in the living eye
Abstract
Adaptive optics imaging of cone photoreceptors has provided unique insight into the structure and function of the human visual system and has become an important tool for both basic scientists and clinicians. Recent advances in adaptive optics retinal imaging instrumentation and methodology have allowed us to expand beyond cone imaging. Multi-wavelength and fluorescence imaging methods with adaptive optics have allowed multiple retinal cell types to be imaged simultaneously. These new methods have recently revealed rod photoreceptors, retinal pigment epithelium (RPE) cells, and the smallest retinal blood vessels. Fluorescence imaging coupled with adaptive optics has been used to examine ganglion cells in living primates. Two-photon imaging combined with adaptive optics can evaluate photoreceptor function non-invasively in the living primate retina.
Figures
Similar articles
-
Retinal Ganglion Cell Death as a Late Remodeling Effect of Photoreceptor Degeneration.Int J Mol Sci. 2019 Sep 19;20(18):4649. doi: 10.3390/ijms20184649. Int J Mol Sci. 2019. PMID: 31546829 Free PMC article. Review.
-
High-Resolution Adaptive Optics in Vivo Autofluorescence Imaging in Stargardt Disease.JAMA Ophthalmol. 2019 Jun 1;137(6):603-609. doi: 10.1001/jamaophthalmol.2019.0299. JAMA Ophthalmol. 2019. PMID: 30896765 Free PMC article.
-
Adaptive optics imaging of the human retina.Prog Retin Eye Res. 2019 Jan;68:1-30. doi: 10.1016/j.preteyeres.2018.08.002. Epub 2018 Aug 27. Prog Retin Eye Res. 2019. PMID: 30165239 Free PMC article. Review.
-
Adaptive optics retinal imaging: emerging clinical applications.Optom Vis Sci. 2010 Dec;87(12):930-41. doi: 10.1097/OPX.0b013e3181ff9a8b. Optom Vis Sci. 2010. PMID: 21057346 Free PMC article.
-
High-resolution retinal imaging of cone-rod dystrophy.Ophthalmology. 2006 Jun;113(6):1019.e1. doi: 10.1016/j.ophtha.2006.01.056. Epub 2006 May 2. Ophthalmology. 2006. PMID: 16650474
Cited by
-
Cone Density Is Correlated to Outer Segment Length and Retinal Thickness in the Human Foveola.Invest Ophthalmol Vis Sci. 2023 Dec 1;64(15):11. doi: 10.1167/iovs.64.15.11. Invest Ophthalmol Vis Sci. 2023. PMID: 38064229 Free PMC article.
-
The role of multimodal imaging and vision function testing in ABCA4-related retinopathies and their relevance to future therapeutic interventions.Ther Adv Ophthalmol. 2021 Dec 19;13:25158414211056384. doi: 10.1177/25158414211056384. eCollection 2021 Jan-Dec. Ther Adv Ophthalmol. 2021. PMID: 34988368 Free PMC article. Review.
-
Progress in Gene Editing Tools and Their Potential for Correcting Mutations Underlying Hearing and Vision Loss.Front Genome Ed. 2021 Oct 28;3:737632. doi: 10.3389/fgeed.2021.737632. eCollection 2021. Front Genome Ed. 2021. PMID: 34778871 Free PMC article. Review.
-
Challenges Associated With Ellipsoid Zone Intensity Measurements Using Optical Coherence Tomography.Transl Vis Sci Technol. 2021 Oct 4;10(12):27. doi: 10.1167/tvst.10.12.27. Transl Vis Sci Technol. 2021. PMID: 34665233 Free PMC article.
-
Thyroid hormone signaling specifies cone photoreceptor subtypes during eye development: Insights from model organisms and human stem cell-derived retinal organoids.Vitam Horm. 2021;116:51-90. doi: 10.1016/bs.vh.2021.03.001. Epub 2021 Mar 10. Vitam Horm. 2021. PMID: 33752828 Free PMC article.
References
-
- Liang J, Grimm B, Goelz S, Bille J. Objective measurement of wave aberrrations of the human eye with the use of a Hartmann-Schack wave-front sensor. J Opt Soc Am A. 1994;11 (7:1949–1957. - PubMed
-
- Liang J, Williams D, Miller D. Supernormal vision and high-resolution retinal imaging through adaptive optics. JOSA-A. 1997;14 (11:2884–2892. - PubMed
-
- Gray DC, Wolfe R, Gee BP, Scoles D, Geng Y, Masella BD, et al. In vivo imaging of the fine structure of rhodamine-labeled macaque retinal ganglion cells. Invest Ophthalmol Vis Sci. 2008;49 (1:467–473. - PubMed
-
- Enoch J. Optical properties of the retinal receptors. J Opt Soc Am. 1963;53 (1:71–85.
-
- Roorda A, Williams D. Optical fiber properties of individual human cones. J Vis. 2002;2:404–412. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical