doi: 10.1016/j.steroids.2011.03.004.
Epub 2011 Mar 16.
Easy stereoselective synthesis of 5α-estrane-3β,17α-diol, the major metabolite of nandrolone in the horse
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- PMID: 21419146
- DOI: 10.1016/j.steroids.2011.03.004
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Easy stereoselective synthesis of 5α-estrane-3β,17α-diol, the major metabolite of nandrolone in the horse
Steroids.
2011 Jun.
Abstract
5α-Estrane-3β,17α-diol is the major metabolite of nandrolone in horse urine. The presence of 5α-estrane-3β,17α-diol in female and gelding urines is prohibited by Racing Rules and its natural presence in male urine led regulation authorities to establish a concentration threshold of 45 ng/mL. This paper describes a rapid, simple and stereoselective synthesis of 5α-estrane-3β,17α-diol, providing horseracing laboratories with an essential reference material for their antidoping performance.
Copyright © 2011 Elsevier Inc. All rights reserved.
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